Yup, the current dominating factor is resistance, not the Landauer limit. Biological systems supposedly operate at about one order of magnitude above the Landa

Yup, the current dominating factor is resistance, not the Landauer limit. Biological systems supposedly operate at about one order of magnitude above the Landauer limit [0], i.e this is completely practical and has been happening before we even made computers... we probably wouldn't exist without being this efficient, imagine how much energy our cells would need to consume and emit as heat if it were similar to a CPU of today! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686401/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5686401/