Elderly people have quite a few incident effects related to their age. The most prominent one - the decrease of mitochondrial function, which leads to a signifi

Elderly people have quite a few incident effects related to their age. The most prominent one - the decrease of mitochondrial function, which leads to a significant loss of ATP yield, which in turn is a huge risk factor of acquiring a dementia by itself. If someone is given aspirin under those conditions, they may experience a worsening because aspirin provokes the release of cytochrome C from mitochondria, thus inducing apoptosis (cell death). This is a well-known effect [0] which may lead to encephalopathy under harsh conditions [1] (in reality regardless of age). At the same time, if someone is being administered aspirin in parallel to a correction of the declining mitochondrial function, the effect is the opposite: marginal cells may still die due to apoptosis, but newer cells will be created to take their functions thanks to the increased neurogenesis as the direct result of a restored anabolism. At the same time, anti-inflammatory effects of NSAID help to suppress a low-grade inflammation in vessels' endothelium. The result is: improved blood flow which in turn helps to restore mitochondrial function even further; the loss of marginal tissues similar to autophagy, improved neurogenesis; and sometimes - dementia reversal. BTW, this is why the results of using NSAIDs are different for younger and older cohorts - younger people have fewer chances of acquiring a compromised mitochondrial function. However, mito problems may occur even in young age due to genetics, environmental conditions, toxins, post-bacterial or post-viral effects caused by oxidative stress. So, this should be kept in mind as NSAIDs may indeed worsen the condition causing damages similar to Reye's syndrome unless they are administered together with a mito protocol. Another important point is that different NSAIDs have different effects. Aspirin is a relatively well-regarded medication, while others may be associated with an increased risk of a heart attack or stroke - which may significantly increase the chances of acquiring a dementia, but in a different way. [0] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1508093/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1508093/ [1] https://pubmed.ncbi.nlm.nih.gov/17147458/#:~:text=Reye's%20syndrome%20is%20a%20serious,teenagers%20%3C18%20years%20of%20age https://pubmed.ncbi.nlm.nih.gov/17147458/#:~:text=Reye's%20s....