2 ms·Yes. Anything that has an effect outside of the digestive system should be suspect.by mcculley 3y agoYes. Anything that has an effect outside of the digestive system should be suspect.danielbln 3y agoThat's.. a lot of things. Even various foods have effects outside of the digestive system.mcculley 3y agoYes. After quitting caffeine I realized I had to be more careful about eating dark chocolate, for example.