3 ms·

See also: MitoQ--a mitochondria-targeted antioxidant that aims to address CoQ10's inefficiencies. https://pubmed.ncbi.nlm.nih.gov/17642004/ https://pubmed.ncbi

by anjel 3y ago

See also: MitoQ--a mitochondria-targeted antioxidant that aims to address CoQ10's inefficiencies. https://pubmed.ncbi.nlm.nih.gov/17642004/ https://pubmed.ncbi.nlm.nih.gov/17642004/ MitoQ is an orally active antioxidant that has the ability to target mitochondrial dysfunction. The agent is currently under development by Antipodean Pharmaceuticals Inc in phase II clinical trials for Parkinson's disease and liver damage associated with HCV infection. MitoQ has demonstrated encouraging preclinical results in numerous studies in isolated mitochondria, cells and tissues undergoing oxidative stress and apoptotic death. MitoQ aims to not only mimic the role of the endogenous mitochondrial antioxidant coenzyme Q10 (CoQ10), but also to augment substantially the antioxidant capacity of CoQ to supraphysiological levels in a mitochondrial membrane potential-dependent manner. MitoQ represents the first foray into the clinic in an attempt to deliver an antioxidant to an intracellular region that is responsible for the formation of increased levels of potentially deleterious reactive oxygen species. Results from the clinical trials with MitoQ will have important repercussions on the relevance of a mitochondrial-targeted approach. See also also: SkQ Skulachev Ions https://en.wikipedia.org/wiki/SkQ https://en.wikipedia.org/wiki/SkQ

fasteo 3y ago
Mitoq failed as a therapeutic option for primary mitochondrial disease. Now, it is sold OTC. As a patient with primary’s mitochondrial disease I have tried mitoq several times. Other than placebo effect, it did not work for me
- deleted 3y ago
  [deleted]
- GenerWork 3y ago
  This may come off sounding more combative than I mean it to, but has anything worked for you, and if so, what's worked?
  - fasteo 3y ago
    There isn't a yes/no answer for this. The disease has no cure and it is progressive, so saying that it worked for me means that it helps me in my day-to-day (fatigue level, vitality, post-exercise recovery, etc), but that's it. I understand that this is highly subjective from the outside, but after trying hundreds of different things I have developed a sixth sense to know what works for me. The most important thing is food. In my case, a lowish-carb diet (around 100 grams/day). Only tubers and rice. I also do 2 keto cycles of 4-6 weeks every year based on this study [1]. It is a pain to go through this, but it seems to do some good in the long run. The second thing is exercise. A combination of weight training and HIIT works great. There is some science behind this. In short: satellite cells are mutation free. Weight training activates them and aerobics makes them "reproduce". This way, I can offset the replication advantage that mutant cells have ("clonal expansion", the force that makes the disease progressive). Third, supplements. Plain CoQ10 in some formulation that improve bio-availability (p.e. Jarrow's Q-absorb). 100-200 mg/day. I can't see additional benefits in larger doses. Plain non-flush niacin (500 mg/day). There is a recent study for this [1] with actual human beings with the very same disease that I have. I also take curcumin and several forms of magnesium daily. They both seem to work. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090656/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090656/ [2] https://doi.org/10.1016/j.cmet.2020.04.008 https://doi.org/10.1016/j.cmet.2020.04.008

by anjel 3y ago

fasteo 3y ago

Mitoq failed as a therapeutic option for primary mitochondrial disease. Now, it is sold OTC. As a patient with primary’s mitochondrial disease I have tried mitoq several times. Other than placebo effect, it did not work for me

deleted 3y ago
[deleted]
GenerWork 3y ago
This may come off sounding more combative than I mean it to, but has anything worked for you, and if so, what's worked?
- fasteo 3y ago
  There isn't a yes/no answer for this. The disease has no cure and it is progressive, so saying that it worked for me means that it helps me in my day-to-day (fatigue level, vitality, post-exercise recovery, etc), but that's it. I understand that this is highly subjective from the outside, but after trying hundreds of different things I have developed a sixth sense to know what works for me. The most important thing is food. In my case, a lowish-carb diet (around 100 grams/day). Only tubers and rice. I also do 2 keto cycles of 4-6 weeks every year based on this study [1]. It is a pain to go through this, but it seems to do some good in the long run. The second thing is exercise. A combination of weight training and HIIT works great. There is some science behind this. In short: satellite cells are mutation free. Weight training activates them and aerobics makes them "reproduce". This way, I can offset the replication advantage that mutant cells have ("clonal expansion", the force that makes the disease progressive). Third, supplements. Plain CoQ10 in some formulation that improve bio-availability (p.e. Jarrow's Q-absorb). 100-200 mg/day. I can't see additional benefits in larger doses. Plain non-flush niacin (500 mg/day). There is a recent study for this [1] with actual human beings with the very same disease that I have. I also take curcumin and several forms of magnesium daily. They both seem to work. [1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090656/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5090656/ [2] https://doi.org/10.1016/j.cmet.2020.04.008 https://doi.org/10.1016/j.cmet.2020.04.008