The Botox-like family are the most potent substances by weight, whether they're used for medication or poison. It's kind of crazy when you consider it. It tak

The Botox-like family are the most potent substances by weight, whether they're used for medication or poison. It's kind of crazy when you consider it. It takes thousands of botox doses to kill you. That's not dissimilar from most drugs- take a thousand advil and you'll certainly die. One unit dose of botox is 50 picograms. A lethal intramuscular dose is ~160 nanograms. A lethal inhaled dose is ~1 microgram. That's crazy. Inject any other chemical into the heart, brain, wherever you want- you will not be able to kill someone with a smaller dose of anything. The next most potent drugs (eg LSD, actually) create perceptible effects at fifty times the lethal dosage of botox. LSD is noticeable at <25 micrograms. Ricin is lethal at 1.6 milligrams. Fentanyl is lethal at 2 milligrams and dosed at 50 micrograms. Even covid the vaccines have 30+ micrograms of RNA that makes the larger amount of protein that trains your immune system. 50 picograms is only ~50,000 individual virus, about half of what is released by the infection of a single cell. Botox is within spitting distance of the lethality of a nuclear fission reaction. 160 nanograms of U-235 releases ~16 kJ, a bit under the energy in two AA batteries or ten 5.56 rifle shots. That's more than enough energy to cauterize a critical cardiac artery, or pop your skull... but it's less than an M80. Realistically (lol) if you pulled 160 nanograms of material from the center of our sun (or probably any star short of a neutron star), it's going to stop fusing immediately since it'll be too busy exploding. I've got no idea what the math on that is, but I'd be pretty surprised if it beat out botox for lethality. Which is crazy.