> They took BPD-specific drugs Is there any good evidence that there are BPD-specific drugs? ----- 2015: Pharmacotherapy for borderline personality disorder-

> They took BPD-specific drugs Is there any good evidence that there are BPD-specific drugs? ----- 2015: Pharmacotherapy for borderline personality disorder--current evidence and recent trends > Abstract > Drug treatment of patients with borderline personality disorder (BPD) is common but mostly not supported by evidence from high-quality research. This review summarises the current evidence up to August 2014 and also aims to identify research trends in terms of ongoing randomised controlled trials (RCTs) as well as research gaps. There is some evidence for beneficial effects by second-generation antipsychotics, mood stabilisers and omega-3 fatty acids, while the overall evidence base is still unsatisfying. The dominating role SSRI antidepressants usually play within the medical treatment of BPD patients is neither reflected nor supported by corresponding evidence. Any drug treatment of BPD patients should be planned and regularly evaluated against this background of evidence. Research trends indicate increasing attention to alternative treatments such as dietary supplementation by omega-3 fatty acids or oxytocin. https://pubmed.ncbi.nlm.nih.gov/25413640/ https://pubmed.ncbi.nlm.nih.gov/25413640/ ----- 2021: Pharmacological Treatments for Borderline Personality Disorder: A Systematic Review and Meta-Analysis > Results > Of 12,062 unique records, we included 21 randomized controlled trials (RCTs) with data on 1768 participants. Nineteen RCTs compared pharmacotherapies with placebo; two RCTs assessed active treatments head-to-head. Out of 87 medications in use in clinical practice, we found studies on just nine. Overall, the evidence indicates that the efficacy of pharmacotherapies for the treatment of BPD is limited. Second-generation antipsychotics, anticonvulsants, and antidepressants were not able to consistently reduce the severity of BPD. Low-certainty evidence indicates that anticonvulsants can improve specific symptoms associated with BPD such as anger, aggression, and affective lability but the evidence is mostly limited to single studies. Second-generation antipsychotics had little effect on the severity of specific BPD symptoms, but they improved general psychiatric symptoms in patients with BPD. > Conclusions > Despite the common use of pharmacotherapies for patients with BPD, the available evidence does not support the efficacy of pharmacotherapies alone to reduce the severity of BPD. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478737/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478737/