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Which is a good argument against medication that just lowers GDF15 levels. But if you approach it as "what lifestyle changes lower GDF15" then there's a good ch
by wongarsu 3y ago
Which is a good argument against medication that just lowers GDF15 levels. But if you approach it as "what lifestyle changes lower GDF15" then there's a good chance that those changes would also attack the actual reason for dementia.
- croshan 3y agoExactly. I know if medication were to be developed, checking "are GDF15 levels significantly lowered" would be part of the trials. But how often does the medication development process check the result we care about: "does this medication then go on to reduce the chance of dementia?"
- wbl 3y agoAlways. Secondary endpoints are heavily disfavored in FDA approval.
- autokad 3y agoyeah strongly agree. it was thought that those plaques in the brain was the cause of alz; however, some research has indicated that's the body's defense against what is going on, not the cause. so you could take a medication that lowers GDF15, and its possible it actually increases the onset of dementia.