NDST1 is a bifunctional sulfotransferase and de-acetylase. It’s a gatekeeper enzyme (well as much as it can gatekeep with other isoenzymes), that catalyses a su

NDST1 is a bifunctional sulfotransferase and de-acetylase. It’s a gatekeeper enzyme (well as much as it can gatekeep with other isoenzymes), that catalyses a sulfation on heparan sulfate (HS) chains. HS makes up a big chunk of the extracellular matrix, and it is this matrix that various signaling molecules travel through to get to the cell. Reducing availability of NDST1 in cells would likely reduce binding of growth factors etc (or increase it, who knows!). It’s likely a bunch of subtle effects, and maybe this is actually pointing to some whole other thing that is happening. It’s difficult to say without digging into the literature.