3 ms·
NDST1 is a funny one in the list. In principle it shouldn’t be out in circulation, so it’s probably a sign that actually what you are seeing is a dysregulation
by hirenj 3y ago
NDST1 is a funny one in the list. In principle it shouldn’t be out in circulation, so it’s probably a sign that actually what you are seeing is a dysregulation in activity of SPPL3 in shedding of this enzyme from the Golgi.
More on reflection: Looks like NDST1 has a protective effect, so maybe this is reflecting the shedding going up for some reason. Would need to check what is regulating SPPL3 activity.
- FollowingTheDao 3y agoNDST1 metabolizes glucosamine. I’m wondering, if taking glucosamine supplements could increase the risk of dementia then.
- hirenj 3y agoNDST1 is a bifunctional sulfotransferase and de-acetylase. It’s a gatekeeper enzyme (well as much as it can gatekeep with other isoenzymes), that catalyses a sulfation on heparan sulfate (HS) chains. HS makes up a big chunk of the extracellular matrix, and it is this matrix that various signaling molecules travel through to get to the cell. Reducing availability of NDST1 in cells would likely reduce binding of growth factors etc (or increase it, who knows!). It’s likely a bunch of subtle effects, and maybe this is actually pointing to some whole other thing that is happening. It’s difficult to say without digging into the literature.