3 ms·

What are the actual papers?

akhayam 3y ago
Not sure which ones, but here is the whole history of Marc's research publications: https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Marc+Tessier-Lavigne&btnG= https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Marc...
drakythe 3y ago
I haven't found a specific list, but did find this article with a bunch more details https://www.statnews.com/2023/07/19/marc-tessier-lavigne-stanford-president-resignation/ https://www.statnews.com/2023/07/19/marc-tessier-lavigne-sta...
sva_ 3y ago
Here's a list if you scroll down and also the altered images with annotations. The photoshopping is pretty brazen. https://stanforddaily.com/2022/11/29/stanford-presidents-research-under-investigation-for-scientific-misconduct-university-admits-mistakes/ https://stanforddaily.com/2022/11/29/stanford-presidents-res...
capableweb 3y ago
> Today, the Stanford board’s special committee released the law firm’s and scientific panels’ findings, which are based on more than 50,000 documents, interviews with over 50 people, and input from forensic science experts. Its report finds that for seven papers on which Tessier-Lavigne was a middle, or secondary, author, he bears no responsibility for any data manipulation. The primary authors have taken responsibility and in many cases are issuing corrections. > But the 22-page report (plus appendices) found “serious flaws” in all five papers on which Tessier-Lavigne is corresponding or senior author: the 1999 Cell paper, the two 2001 Science papers, a 2004 Nature paper, and the 2009 Nature paper from Genentech. In four of these studies, the investigation found “apparent manipulation of research data by others.” For example, in one case, a single blot from the 2009 Cell paper was used in three different experiments, and a blot from that paper was reused in one of the 2001 Science papers. > The 2004 Nature paper also contains manipulated images, the report found. Although the report says the allegations of fraud and a cover-up at Genentech involving the 2009 Nature paper were “mistaken”—people likely conflated the fraudulent paper a year earlier, and Genentech scientists’ problems replicating the work, it suggests—that paper showed “a lack of rigor” that falls below standards. https://www.science.org/content/article/stanford-president-to-step-down-despite-probe-exonerating-him-of-research-misconduct https://www.science.org/content/article/stanford-president-t... PubPeer alsoshows which papers they've been involved with that has "Errata" or "Expression of Concern": https://pubpeer.com/search?q=authors%3A+%22tessier-lavigne%22 https://pubpeer.com/search?q=authors%3A+%22tessier-lavigne%2...
entrepy123 3y ago
TL;DR: References [1-3] further below are the direct answer to your question, "What are the actual papers?" (the "3 papers" referenced in the submission title; those that it is said that Tessier-Lavigne will retract). The PubMed links are as follows: - https://pubmed.ncbi.nlm.nih.gov/10399920/ https://pubmed.ncbi.nlm.nih.gov/10399920/ - https://pubmed.ncbi.nlm.nih.gov/11239160/ https://pubmed.ncbi.nlm.nih.gov/11239160/ - https://pubmed.ncbi.nlm.nih.gov/15510105/ https://pubmed.ncbi.nlm.nih.gov/15510105/ To elaborate: From [0], "...To date, all three of these papers (Cell ’99, Science ’01 Binding, Science ’01 Silencing) remain published....Dr. Tessier-Lavigne has stated to the Panel that he intends to retract all three papers." Also from [0], "As to the five reviewed papers where Dr. Tessier-Lavigne was a principal author...Specifically, a group of three papers contain images that are the result of manipulation of research data (Cell ’99, Science ’01 Binding, Science ’01 Silencing)...A fourth primary paper also contains images (which Dr. Tessier-Lavigne did not personally prepare) that indicate manipulation of research data (Nature ’04)....The Panel understands that Dr. Tessier-Lavigne now intends to retract at least three publications on which he is a principal author". For the four papers named in the quotes above, citations and links appear below [1-4]. I'd suggest reading [0] (as linked from OP's article) for more details. There are other papers discussed in [0], too. [0] https://boardoftrustees.stanford.edu/wp-content/uploads/sites/5/2023/07/Scientific-Panel-Final-Report.pdf [1] Cell ’99: Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell. 1999;97(7):927-941. doi:10.1016/s0092-8674(00)80804-1, https://pubmed.ncbi.nlm.nih.gov/10399920/ [2] Science ’01 Binding: Stein E, Zou Y, Poo M, Tessier-Lavigne M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science. 2001;291(5510):1976-1982. doi:10.1126/science.1059391, https://pubmed.ncbi.nlm.nih.gov/11239160/ [3] Science ’01 Silencing: Stein E, Tessier-Lavigne M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science. 2001;291(5510):1928-1938. doi:10.1126/science.1058445, https://pubmed.ncbi.nlm.nih.gov/11239147/ [4] Nature ’04: Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004;432(7014):179-186. doi:10.1038/nature03080, https://pubmed.ncbi.nlm.nih.gov/15510105/```

Not sure which ones, but here is the whole history of Marc's research publications: https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Marc+Tessier-Lavigne&btnG= https://scholar.google.com/scholar?hl=en&as_sdt=0%2C5&q=Marc...

drakythe 3y ago

I haven't found a specific list, but did find this article with a bunch more details https://www.statnews.com/2023/07/19/marc-tessier-lavigne-stanford-president-resignation/ https://www.statnews.com/2023/07/19/marc-tessier-lavigne-sta...

sva_ 3y ago

Here's a list if you scroll down and also the altered images with annotations. The photoshopping is pretty brazen. https://stanforddaily.com/2022/11/29/stanford-presidents-research-under-investigation-for-scientific-misconduct-university-admits-mistakes/ https://stanforddaily.com/2022/11/29/stanford-presidents-res...

capableweb 3y ago

> Today, the Stanford board’s special committee released the law firm’s and scientific panels’ findings, which are based on more than 50,000 documents, interviews with over 50 people, and input from forensic science experts. Its report finds that for seven papers on which Tessier-Lavigne was a middle, or secondary, author, he bears no responsibility for any data manipulation. The primary authors have taken responsibility and in many cases are issuing corrections. > But the 22-page report (plus appendices) found “serious flaws” in all five papers on which Tessier-Lavigne is corresponding or senior author: the 1999 Cell paper, the two 2001 Science papers, a 2004 Nature paper, and the 2009 Nature paper from Genentech. In four of these studies, the investigation found “apparent manipulation of research data by others.” For example, in one case, a single blot from the 2009 Cell paper was used in three different experiments, and a blot from that paper was reused in one of the 2001 Science papers. > The 2004 Nature paper also contains manipulated images, the report found. Although the report says the allegations of fraud and a cover-up at Genentech involving the 2009 Nature paper were “mistaken”—people likely conflated the fraudulent paper a year earlier, and Genentech scientists’ problems replicating the work, it suggests—that paper showed “a lack of rigor” that falls below standards. https://www.science.org/content/article/stanford-president-to-step-down-despite-probe-exonerating-him-of-research-misconduct https://www.science.org/content/article/stanford-president-t... PubPeer alsoshows which papers they've been involved with that has "Errata" or "Expression of Concern": https://pubpeer.com/search?q=authors%3A+%22tessier-lavigne%22 https://pubpeer.com/search?q=authors%3A+%22tessier-lavigne%2...

entrepy123 3y ago

TL;DR: References [1-3] further below are the direct answer to your question, "What are the actual papers?" (the "3 papers" referenced in the submission title; those that it is said that Tessier-Lavigne will retract). The PubMed links are as follows: - https://pubmed.ncbi.nlm.nih.gov/10399920/ https://pubmed.ncbi.nlm.nih.gov/10399920/ - https://pubmed.ncbi.nlm.nih.gov/11239160/ https://pubmed.ncbi.nlm.nih.gov/11239160/ - https://pubmed.ncbi.nlm.nih.gov/15510105/ https://pubmed.ncbi.nlm.nih.gov/15510105/ To elaborate: From [0], "...To date, all three of these papers (Cell ’99, Science ’01 Binding, Science ’01 Silencing) remain published....Dr. Tessier-Lavigne has stated to the Panel that he intends to retract all three papers." Also from [0], "As to the five reviewed papers where Dr. Tessier-Lavigne was a principal author...Specifically, a group of three papers contain images that are the result of manipulation of research data (Cell ’99, Science ’01 Binding, Science ’01 Silencing)...A fourth primary paper also contains images (which Dr. Tessier-Lavigne did not personally prepare) that indicate manipulation of research data (Nature ’04)....The Panel understands that Dr. Tessier-Lavigne now intends to retract at least three publications on which he is a principal author". For the four papers named in the quotes above, citations and links appear below [1-4]. I'd suggest reading [0] (as linked from OP's article) for more details. There are other papers discussed in [0], too. [0] https://boardoftrustees.stanford.edu/wp-content/uploads/sites/5/2023/07/Scientific-Panel-Final-Report.pdf [1] Cell ’99: Hong K, Hinck L, Nishiyama M, Poo MM, Tessier-Lavigne M, Stein E. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell. 1999;97(7):927-941. doi:10.1016/s0092-8674(00)80804-1, https://pubmed.ncbi.nlm.nih.gov/10399920/ [2] Science ’01 Binding: Stein E, Zou Y, Poo M, Tessier-Lavigne M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science. 2001;291(5510):1976-1982. doi:10.1126/science.1059391, https://pubmed.ncbi.nlm.nih.gov/11239160/ [3] Science ’01 Silencing: Stein E, Tessier-Lavigne M. Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex. Science. 2001;291(5510):1928-1938. doi:10.1126/science.1058445, https://pubmed.ncbi.nlm.nih.gov/11239147/ [4] Nature ’04: Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature. 2004;432(7014):179-186. doi:10.1038/nature03080, https://pubmed.ncbi.nlm.nih.gov/15510105/```