4 ms·
Seems like the special sauce is nothing at all but what seems to be well known prior art: [0038] In preparing the xenograft for use, the tendon is surgical
by AYBABTME 3y ago
Seems like the special sauce is nothing at all but what seems to be well known prior art:
[0038] In preparing the xenograft for use, the tendon is surgically
dissected and removed from the paratenon (tendon sheath). The tendon is
composed mostly of an extra-cellular collagen matrix, which is non-
immunogenic. The tendon may therefore require no denaturing
(decellularisation) prior to implantation into a mammal. In some
embodiments, the tendon may be subjected to a decellularisation process
prior to implantation. In removing the cells from the tendon, the
immunogenic antibodies within the cells are also removed, thus rendering the
tendon non- immunogenic. Methods of decellularisation of tendon tissue are
known in the art. Such methods include physical, chemical and enzymatic
treatments, wherein the cells within the tendon are lysed, leaving an
undamaged extracellular matrix having the same physical and biochemical
properties as the natural tissue.
- koheripbal 3y agoThis was tried with pig tendons about 20 years ago. I wonder what has changed.
- tourmalinetaco 3y agoFrom a cursory glance, the animal.
- AYBABTME 3y agoYeah seems like kangaroo tendons are much stronger than pig/cow ones. Per the article.
- midoridensha 3y agoSeems pretty obvious, considering the way kangaroo legs work. I'm surprised it took people this long to figure this out, though I guess since pigs and cows are eaten as food so much, there's a huge surplus of their tendons, unlike kangaroos'.
- zeruch 3y agoTHere are more Kangaroos than people in Australia, and while it is a food source, there is ample surplus.
- tourmalinetaco 3y agoThough according to both the article and comments ITT, kangaroo meat isn’t unheard of in Australia so a surplus does exist. Probably not one for a global application of this procedure, but enough for experimentation. Perhaps by the time we perfect this lab-grown tendons may be a superior source, or other animals can be used.