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The unique relationship between nasal cavity and cranial cavity tissues in anatomy and physiology makes intranasal delivery to the brain feasible. An intranasal

The unique relationship between nasal cavity and cranial cavity tissues in anatomy and physiology makes intranasal delivery to the brain feasible. An intranasal delivery provides some drugs with short channels to bypass the blood-brain barrier (BBB), especially for those with fairly low brain concentrations after a routine delivery, thus greatly enhancing the therapeutic effect on brain diseases. https://pubmed.ncbi.nlm.nih.gov/18817519/ https://pubmed.ncbi.nlm.nih.gov/18817519/ https://en.wikipedia.org/wiki/Olfactory_bulb https://en.wikipedia.org/wiki/Olfactory_bulb https://en.wikipedia.org/wiki/Olfactory_nerve https://en.wikipedia.org/wiki/Olfactory_nerve I have heard that the brain kind of sticks out into the sinuses, which may not be technically correct but the illustrations etc above show that there is a uniquely direct connection between the sinuses and brain via nerves that pass through very little tissue at a minimum.

matheusmoreira 3y ago
The olfactory nerve extends directly from the brain. It is the first cranial nerve pair. https://en.wikipedia.org/wiki/Cranial_nerves https://en.wikipedia.org/wiki/Cranial_nerves The nerve forms a bulb directly above the nasal cavity. That bulb emits many smaller projections through the skull and into the nasal cavity. https://en.wikipedia.org/wiki/Cribriform_plate https://en.wikipedia.org/wiki/Cribriform_plate https://en.wikipedia.org/wiki/Olfactory_foramina https://en.wikipedia.org/wiki/Olfactory_foramina The nerves pass through those holes in the bone which are called olfactory foramina. Foramen means hole and these foramina connect the cranial cavity to the nasal cavity. The paranasal sinuses are nearby structures. The olfactory nerves do not go in there. It's absolutely a fact that the nose is pretty much directly connected to the brain though. The best demonstration of this fact is naegleriasis: https://en.wikipedia.org/wiki/Naegleria_fowleri https://en.wikipedia.org/wiki/Naegleria_fowleri https://en.wikipedia.org/wiki/Naegleriasis https://en.wikipedia.org/wiki/Naegleriasis This thing lives in water. If that water enters your nasal cavity, it will travel via olfactory nerve to your brain where it will proceed to literally eat it.

matheusmoreira 3y ago

The olfactory nerve extends directly from the brain. It is the first cranial nerve pair. https://en.wikipedia.org/wiki/Cranial_nerves https://en.wikipedia.org/wiki/Cranial_nerves The nerve forms a bulb directly above the nasal cavity. That bulb emits many smaller projections through the skull and into the nasal cavity. https://en.wikipedia.org/wiki/Cribriform_plate https://en.wikipedia.org/wiki/Cribriform_plate https://en.wikipedia.org/wiki/Olfactory_foramina https://en.wikipedia.org/wiki/Olfactory_foramina The nerves pass through those holes in the bone which are called olfactory foramina. Foramen means hole and these foramina connect the cranial cavity to the nasal cavity. The paranasal sinuses are nearby structures. The olfactory nerves do not go in there. It's absolutely a fact that the nose is pretty much directly connected to the brain though. The best demonstration of this fact is naegleriasis: https://en.wikipedia.org/wiki/Naegleria_fowleri https://en.wikipedia.org/wiki/Naegleria_fowleri https://en.wikipedia.org/wiki/Naegleriasis https://en.wikipedia.org/wiki/Naegleriasis This thing lives in water. If that water enters your nasal cavity, it will travel via olfactory nerve to your brain where it will proceed to literally eat it.