I’d be a little skeptical about spraying in a bunch of heparin and hoping it binds enough of the spike protein. This whole idea is predicated on the binding of

I’d be a little skeptical about spraying in a bunch of heparin and hoping it binds enough of the spike protein. This whole idea is predicated on the binding of heparin (a sulfated polysaccharide) to the spike. It’s known to be a co-receptor on cells for the spike protein, and people have designed very clever flow devices to exploit this binding to perform detection of spike. However, without carefully controlling the sulfation on heparin, I would be worried about all the other binding of proteins, and how effective this would be in real complex environments. There are also open questions about how you would even retain the GAGs in the mucosal environment, and as I haven’t heard that they bind to mucins/mucus, I wonder how many other proteins they could possibly anchor to.