“With this new method, the researchers were able to observe the sequence recognition by the CRISPR Cascade complex almost base pair by base pair. Surprisingly,

“With this new method, the researchers were able to observe the sequence recognition by the CRISPR Cascade complex almost base pair by base pair. Surprisingly, base pairing with the RNA is not energetically advantageous, meaning that the complex is only unstably bound during sequence recognition. Only when the entire sequence is recognized does stable binding occur and the DNA is subsequently destroyed. If it is the "wrong" target sequence, the process is aborted.”