I think the search for tiny effects and the belief that they should drive treatment, is one of the biggest things wrong with medical research. Doctors will put

I think the search for tiny effects and the belief that they should drive treatment, is one of the biggest things wrong with medical research. Doctors will put millions of people on a pill that hits a vital metabolic pathway, for life, based on tiny (to my thinking) statistically significant (i.e. only a 5% chance they aren't based on a real effect) results. These days I only believe large effects- like smoking causes heart disease