9 ms·

Excuse my apparently elementary school reading level but where does that passage say anything about concentrations?

by dataflow 3y ago

hedora 3y ago
The last sentence says the necessary concentrations vary wildly, and no one understands why.
- dataflow 3y ago
  If it does, it certainly isn't obvious to me. Which part of it concerns concentration? E.g. Is concentration a "toxicokinetic property"?
  - aydyn 3y ago
    Yes, it's that: "Toxicokinetics describes how the body handles a chemical, as a function of dose and time"
    - dataflow 3y ago
      If I understand that correctly, is that not a different thing? It sounds like that's a derivative (the rate of absorption/metabolism/etc.), rather than the concentration at which the chemical become harmful? Or is the concentration itself also included in the "kinetics"?
      - aydyn 3y ago
        Its the same thing. scientists in all fields like to use big technical sounding words. Dont read too muchinto it.
gostsamo 3y ago
If I'm not mistaken, it says it in the part with "epidemiological". It means that the study is made by observing real life developments instead of poisoning people in the name of science.
- dataflow 3y ago
  Interesting. Does that imply a study of the "average person", so to speak? Or might it be a study of people whose (say) PFAS exposures were suspected to be high, for whatever reason?
  - gostsamo 3y ago
    so much time passed and you haven't read it yet?! Are you actually interested in the answers?
    - dataflow 3y ago
      "So much time" has been like half a day, much of which is in the middle of a work day? No, I genuinely haven't had the time to sit down and read this in detail. Do I need to detail what's going on in my life here?
Dah00n 3y ago
aydyn posted this in the above thread: "A doubling of perfluorooctane sulfonate (PFOS) in maternal serum was associated with a 39% (p < 0.001) reduction in diphtheria antibody concentration in children (age 5 yr), with increased odds of falling below clinically protective values against diphtheria and tetanus at age 7 yr." > A study of heavily exposed workers (n = 462, geometric mean serum PFOA of 4048 ng/mL) detected significantly increased incident mortality for cirrhosis (relative risk = 3.87, 95% CI 1.18–12.7) and liver cancer (relative risk = 6.69, 95% CI 1.71–26.2)
- dataflow 3y ago
  I saw that but doubling from what concentration to what, though? Are they the same concentration normal people are exposed to?

Excuse my apparently elementary school reading level but where does that passage say anything about concentrations?

hedora 3y ago

The last sentence says the necessary concentrations vary wildly, and no one understands why.

dataflow 3y ago
If it does, it certainly isn't obvious to me. Which part of it concerns concentration? E.g. Is concentration a "toxicokinetic property"?
- aydyn 3y ago
  Yes, it's that: "Toxicokinetics describes how the body handles a chemical, as a function of dose and time"
  - dataflow 3y ago
    If I understand that correctly, is that not a different thing? It sounds like that's a derivative (the rate of absorption/metabolism/etc.), rather than the concentration at which the chemical become harmful? Or is the concentration itself also included in the "kinetics"?
    - aydyn 3y ago
      Its the same thing. scientists in all fields like to use big technical sounding words. Dont read too muchinto it.

gostsamo 3y ago

If I'm not mistaken, it says it in the part with "epidemiological". It means that the study is made by observing real life developments instead of poisoning people in the name of science.

dataflow 3y ago
Interesting. Does that imply a study of the "average person", so to speak? Or might it be a study of people whose (say) PFAS exposures were suspected to be high, for whatever reason?
- gostsamo 3y ago
  so much time passed and you haven't read it yet?! Are you actually interested in the answers?
  - dataflow 3y ago
    "So much time" has been like half a day, much of which is in the middle of a work day? No, I genuinely haven't had the time to sit down and read this in detail. Do I need to detail what's going on in my life here?

Dah00n 3y ago

aydyn posted this in the above thread: "A doubling of perfluorooctane sulfonate (PFOS) in maternal serum was associated with a 39% (p < 0.001) reduction in diphtheria antibody concentration in children (age 5 yr), with increased odds of falling below clinically protective values against diphtheria and tetanus at age 7 yr." > A study of heavily exposed workers (n = 462, geometric mean serum PFOA of 4048 ng/mL) detected significantly increased incident mortality for cirrhosis (relative risk = 3.87, 95% CI 1.18–12.7) and liver cancer (relative risk = 6.69, 95% CI 1.71–26.2)

dataflow 3y ago
I saw that but doubling from what concentration to what, though? Are they the same concentration normal people are exposed to?