degenerative conditions are not exactly "triggered" ; for a very bad analogy, consider the difference between a leaky auto tire and one that has a sudden punctu

degenerative conditions are not exactly "triggered" ; for a very bad analogy, consider the difference between a leaky auto tire and one that has a sudden puncture. Human beings have evolved to maintain biological function for survival; partial functionality, imperfect execution, less-than-wonderful judgement can go on for years and years; nutrition and sleep, emotional context, and yes, drugs use and abuse, contribute to wear and tear.