4 ms·

Best ignore this study then... https://pubmed.ncbi.nlm.nih.gov/24262485/ https://pubmed.ncbi.nlm.nih.gov/24262485/ "A case study involving allergic reactions t

Best ignore this study then... https://pubmed.ncbi.nlm.nih.gov/24262485/ https://pubmed.ncbi.nlm.nih.gov/24262485/ "A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides"

arthur2e5 3y ago
Imagine holding some study that can't even read a structural formula as the holy grail. The big R on any sulfonamide means that there's no "common SO3" as mentioned in the abstract. Disregarding that, just pull up any sulfonamide antibiotic and tell me where you plan to magick the benzene ring from. Or tell me why an also "sulfonamide" diabetes drug is not antibacterial.
- darkclouds 3y ago
  "Penicillin I and IV have no characteristic u.v. absorption, but penicillin II and III show clearly the fine structure of a benzene ring." https://www.nobelprize.org/uploads/2018/06/chain-lecture.pdf https://www.nobelprize.org/uploads/2018/06/chain-lecture.pdf Not all antibiotics will have a benzene ring, besides benzene is carcinogenic, and some penicillin's will be metabolised into penicillamine which depletes the body of metals including copper, useful for treating Wilsons Disease. https://en.wikipedia.org/wiki/Penicillamine#History https://en.wikipedia.org/wiki/Penicillamine#History Low copper leads to lower levels of interleukin 6, which is a particularly useful part of the immune system for targeting some cancers, ergo some antibiotics with their benzene ring and copper chelating properties, increases the risk of cancer... I assume you refer to the Hypoglycaemic Sulfonamides? https://pubmed.ncbi.nlm.nih.gov/9463023/#:~:text=As%20a%20function%20of%20their,circadian%20drop%20in%20insulin%20sensitivity%20 https://pubmed.ncbi.nlm.nih.gov/9463023/#:~:text=As%20a%20fu...( I know antibiotics are a hot topic for a variety of reasons, including the fact that livestock fed antibiotics increase muscle mass, perhaps this is why here in the UK Redbull and other taurine rich energy drinks are banned to under 16yr olds on the pretence the caffeine is the greater enemy, because they dont want stacked as in muscular teenagers running around. https://en.wikipedia.org/wiki/Effect_of_psychoactive_drugs_on_animals https://en.wikipedia.org/wiki/Effect_of_psychoactive_drugs_o... I think this also shows that what constitutes an antibiotic varies enormously, unless the definition of an antibiotic is one that includes the carcinogenic benzene ring? Surprised you haven't mentioned how vitamin K1 disrupts bacterial biofilms, and is particularly useful for tackling pseudomonas, a particularly nasty and stubborn bacteria. Of course its not classed as an antibiotic, its classed as a vitamin, but even the definition of vitamins are being called into doubt when considering pathways that exist in the body, they werent known when the definition of vitamin or "vital amine" were agreed, so maybe the medical profession need to update their terminology in order to not mislead the public en-masse? https://www.researchgate.net/figure/The-kynurenine-pathway-Tryptophan-is-converted-to-kynurenine-by-either-indoleamine_fig1_264629880 https://www.researchgate.net/figure/The-kynurenine-pathway-T...

arthur2e5 3y ago

Imagine holding some study that can't even read a structural formula as the holy grail. The big R on any sulfonamide means that there's no "common SO3" as mentioned in the abstract. Disregarding that, just pull up any sulfonamide antibiotic and tell me where you plan to magick the benzene ring from. Or tell me why an also "sulfonamide" diabetes drug is not antibacterial.

darkclouds 3y ago
"Penicillin I and IV have no characteristic u.v. absorption, but penicillin II and III show clearly the fine structure of a benzene ring." https://www.nobelprize.org/uploads/2018/06/chain-lecture.pdf https://www.nobelprize.org/uploads/2018/06/chain-lecture.pdf Not all antibiotics will have a benzene ring, besides benzene is carcinogenic, and some penicillin's will be metabolised into penicillamine which depletes the body of metals including copper, useful for treating Wilsons Disease. https://en.wikipedia.org/wiki/Penicillamine#History https://en.wikipedia.org/wiki/Penicillamine#History Low copper leads to lower levels of interleukin 6, which is a particularly useful part of the immune system for targeting some cancers, ergo some antibiotics with their benzene ring and copper chelating properties, increases the risk of cancer... I assume you refer to the Hypoglycaemic Sulfonamides? https://pubmed.ncbi.nlm.nih.gov/9463023/#:~:text=As%20a%20function%20of%20their,circadian%20drop%20in%20insulin%20sensitivity%20 https://pubmed.ncbi.nlm.nih.gov/9463023/#:~:text=As%20a%20fu...( I know antibiotics are a hot topic for a variety of reasons, including the fact that livestock fed antibiotics increase muscle mass, perhaps this is why here in the UK Redbull and other taurine rich energy drinks are banned to under 16yr olds on the pretence the caffeine is the greater enemy, because they dont want stacked as in muscular teenagers running around. https://en.wikipedia.org/wiki/Effect_of_psychoactive_drugs_on_animals https://en.wikipedia.org/wiki/Effect_of_psychoactive_drugs_o... I think this also shows that what constitutes an antibiotic varies enormously, unless the definition of an antibiotic is one that includes the carcinogenic benzene ring? Surprised you haven't mentioned how vitamin K1 disrupts bacterial biofilms, and is particularly useful for tackling pseudomonas, a particularly nasty and stubborn bacteria. Of course its not classed as an antibiotic, its classed as a vitamin, but even the definition of vitamins are being called into doubt when considering pathways that exist in the body, they werent known when the definition of vitamin or "vital amine" were agreed, so maybe the medical profession need to update their terminology in order to not mislead the public en-masse? https://www.researchgate.net/figure/The-kynurenine-pathway-Tryptophan-is-converted-to-kynurenine-by-either-indoleamine_fig1_264629880 https://www.researchgate.net/figure/The-kynurenine-pathway-T...