Have a look to Neuron / Core neuron (https://www.neuron.yale.edu/neuron/ https://www.neuron.yale.edu/neuron/ / https://github.com/BlueBrain/CoreNeuron https://g

Have a look to Neuron / Core neuron (https://www.neuron.yale.edu/neuron/ https://www.neuron.yale.edu/neuron/ / https://github.com/BlueBrain/CoreNeuron https://github.com/BlueBrain/CoreNeuron), Nest (https://www.nest-simulator.org/ https://www.nest-simulator.org/) and for the ultra low level STEPS (https://github.com/CNS-OIST/STEPS https://github.com/CNS-OIST/STEPS). For most computational neuroscientist, they are the bread and butter.