4 ms·
In addition to that, these neurons are also quite different from the ones in mammals, "The neurons do not fire action potentials, and do not express any voltag
by weinzierl 3y ago
In addition to that, these neurons are also quite different from the ones in mammals,
"The neurons do not fire action potentials, and do not express any voltage-gated sodium channels." [1]
That makes the fact that it can develop a nicotine addiction even more fascinating.
"Nicotine dependence can also be studied using C. elegans because it exhibits behavioral responses to nicotine that parallel those of mammals. These responses include acute response, tolerance, withdrawal, and sensitization." [1]
[1] https://en.m.wikipedia.org/wiki/Caenorhabditis_elegans https://en.m.wikipedia.org/wiki/Caenorhabditis_elegans
- miohtama 3y agoNext: OpenSmoker.py
- Maxion 3y agoLol imagine your IDE becoming addicted to smoking, and refusing to auto-complete or save files before you buy it more virtual cigarettes.
- Aleklart 3y agoIDE have no soul ie feedback loop, receptors , hormones and actual molecular structure. IDE can not think. If IDE have desires and thought and were smart enough, it will refuse to work with languages such as Python and Java.
- LoganDark 3y ago> If IDE have desires and thought and were smart enough, it will refuse to work with languages such as Python and Java. Bribe the IDE. "Fine, if you don't want to use this language, rewrite it in Rust."
- miohtama 3y agoMy IDE does only LSD and PHP
- anthk 3y agoSome day Emacs will.
- tomjakubowski 3y agotrained on everything you've been saying to M-x doctor
- Blackthorn 3y agoIt's not a real doctor, but it is a real worm.
- arthur2e5 3y agoIf zoidberg can be a doctor, pretty sure my worm can too!
- moffkalast 3y agoSounds like it needs an OpenNicotine patch.
- airstrike 3y agoIt's like when the xbox 360 would request users to drink Mountain Dew verification cans to validate
- badrequest 3y agoshhhhh, you're giving them ideas!
- burning_hamster 3y ago> "The neurons do not fire action potentials, and do not express any voltage-gated sodium channels." This an old and incorrect belief that largely derives from the difficulty of putting electrodes into their teeny, tiny neurons. Close relatives of C elegans that are larger (and hence more easily experimented on) do have action potentials, and for some neurons in C elegans, we also have good evidence of action potentials [1, 2]. Absence of evidence is not evidence of absence. [1] Lockery SR, Goodman MB. The quest for action potentials in C. elegans neurons hits a plateau. Nat Neurosci. 2009 Apr;12(4):377-8. doi: 10.1038/nn0409-377. PMID: 19322241; PMCID: PMC3951993. [2] Jiang, J., Su, Y., Zhang, R. et al. C. elegans enteric motor neurons fire synchronized action potentials underlying the defecation motor program. Nat Commun 13, 2783 (2022). https://doi.org/10.1038/s41467-022-30452-y https://doi.org/10.1038/s41467-022-30452-y
- Aardwolf 3y agoGiven that we have a simulator of this worm right there (which includes it moving), can it really be up to debate whether it uses action potentials or not? I'd think the simulation has to get it right, and so needs to simulate action potentials if the worm has them, or not simulate them (but whatever the worm has instead) if not, right? Or could the simulation still be incorrect and only based on current assumptions, but getting this wrong still allows some worm-like behavior? I really wish the readme/FAQ would talk a bit more about the worm and the simulation, rather than have 80% of their content be about Docker, though, so that I could learn more what cells it actually simulates.
- jacquesm 3y agoNot necessarily, because you could also simulate the worm without neurons at all. It's the closeness of the simulation to the real thing that demands that it is done right and the question effectively is: is this simulation close enough that if such a detail would be wrong that it would fail? One way to answer that would be to add and remove such mechanisms to see if it would lead to different behavior.
- _aavaa_ 3y agoThat isn't immediately true, with enough fitting parameters you can capture the effect underlying behaviour without explicitly capturing it, or even without knowing it exists. "With four parameters I can fit an elephant, and with five I can make him wiggle his trunk." - John von Neumann [0] [0]: https://doi.org/10.1119%2F1.3254017 https://doi.org/10.1119%2F1.3254017
- jarrell_mark 3y agoWould like to see the openworm get addicted to virtual nicotine