You're posting hearsay and anecdote and passing it off as "thousands of years of spiritual practice". As I said, we don't have a good theory of why some people

You're posting hearsay and anecdote and passing it off as "thousands of years of spiritual practice". As I said, we don't have a good theory of why some people have lasting, negative side effects from using these drugs. Anyone claiming otherwise is just wrong. Dressing up your speculation with words like "integration, set/setting, mentors, etc" doesn't make it any less speculative. It's also obvious why you believe this stuff: because it makes you feel more secure in your own use of these substances. It's much harder to admit that you're rolling the dice when you fuck around with your brain chemistry.