If you note, most of these drugs are parenteral (injected IV). It’s a bitch to manufacturer because standards are so high. So what happens is profits get sque

If you note, most of these drugs are parenteral (injected IV). It’s a bitch to manufacturer because standards are so high. So what happens is profits get squeezed, someone runs a bad batch and throws it out, while another company is like “nah, we don’t want to make this any more” and poof, shortage. Of course someone will step in eventually, charge 10x the price, and get bad press for “cost of lifesaving cancer drug increases by 1000% percent”.