If you think about it in terms of many gigabit/s but also in terms of causing "intermittent" application issues I would say it isn't something that can be consi

If you think about it in terms of many gigabit/s but also in terms of causing "intermittent" application issues I would say it isn't something that can be considered negligible. .04% sure but 4% is noticable imho. When I was working in networking, I've had a couple of problems I resolved in the lines of "we have 10% packet loss but only to this specific site" which took non-negligible man-hours to resolve. It is significant enough for some sensitive customers (especially gaming servers and such) to require support on it.