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There's another factor: hunger is proportional to weight via leptin resistance. If you have normal genes and can get to a slightly underweight state, then you s
by sacnoradhq 3y ago
There's another factor: hunger is proportional to weight via leptin resistance. If you have normal genes and can get to a slightly underweight state, then you should have improved leptin sensitivity and eat slightly less. I noticed this factor as my grandfather lost weight, ate less, and it became a vicious cycle where he struggled to maintain weight. Also as I gained weight, I became hungrier and hungrier. I'm on Wegovy now.
- pier25 3y agoDoes Wegovy work?
- sacnoradhq 3y agoOh yeah it works. Take 4 bites and feel full. Hunger is normal/slightly reduced but satiation is rapidly reached. There is an echo of hunger when actual satiation isn't achieved about 20-30 minutes later because the body is operating more on the side of keto and anaerobic. Another downside to the semiglutide autoinjector is it requires cold chain refrigeration. While the autoinjector is damn overengineered and barely noticeable, oral semiglutide should be available around 2024. If that doesn't require a cold chain, that would be a massive improvement.