5 ms·

tl;dr probably from a sick animal, maybe from a lab, no smoking gun either way. Probably not engineered or lab-adapted.

by heyitsguay 3y ago

freitzkriesler2 3y ago
[flagged]
- johndotsun 3y ago
  The virus having been accidentally released from the lab doesn't require that the virus was modified in or by the lab between the time of leak and the time of collection.
  - photochemsyn 3y ago
    No, but a virus suddenly showing up that was pre-adapted to replication in human bodies and didn't follow the usual zoonotic origin scenario of traceable series of mutations over time in both animal and human hosts, along with the sudden appearance of a furin cleavage site not found in any other relatives of said virus, points to (1) likely serial passage through human-gene-modified mice and human cell cultures and (2) CRISPR-related insertion of a human-like furin cleavage site into the adapted virus. This kind of research is dangerous and the risks far outweigh any putative benefits. There are literally hundreds of mammalian viruses out in nature that pose zero risk to humans but which could be modified by these procedures to generate novel pandemic diseases with which the human immune system has had no prior experience.
    - reeaper 3y ago
      [flagged]
    - freitzkriesler2 3y ago
      Great comment but the down d00ters can't handle using common sense and will happily swallow any narrative told to them by talking heads.
baja_blast 3y ago
> Probably not engineered or lab-adapted. Despite having a novel furin cleavage site in the exact location as stated in a grant proposal, a furin cleavage site that happens to make the virus extremely infectious towards humans all while leaving no trace of how it adapted this feature. This seems to me more like a desperate attempt to avoid any regulations or attention drawn to this reckless research conducted all over the world!
- lamontcg 3y ago
  A PRRA furin cleavage site that was a previously unknown sequence and not something that a scientist would have copied off some other virus.
  - BasedAnon 3y ago
    But one that could definitely emerge via gain of function.
    - lamontcg 3y ago
      No, it is amazingly unlikely that you'd see an insertion like that arise through some kind of random serial passage. In nature that happens by recombination which takes many millions of infections to emerge. In the lab you are just replicating that process by serial passage through animals where you might have a dozen animals serially infected. And the chances are probably lower because it is less likely the lab animals would wind up coinfected with another virus that would act as the source material. "Gain of function" research isn't magic.

tl;dr probably from a sick animal, maybe from a lab, no smoking gun either way. Probably not engineered or lab-adapted.

freitzkriesler2 3y ago

[flagged]

johndotsun 3y ago
The virus having been accidentally released from the lab doesn't require that the virus was modified in or by the lab between the time of leak and the time of collection.
- photochemsyn 3y ago
  No, but a virus suddenly showing up that was pre-adapted to replication in human bodies and didn't follow the usual zoonotic origin scenario of traceable series of mutations over time in both animal and human hosts, along with the sudden appearance of a furin cleavage site not found in any other relatives of said virus, points to (1) likely serial passage through human-gene-modified mice and human cell cultures and (2) CRISPR-related insertion of a human-like furin cleavage site into the adapted virus. This kind of research is dangerous and the risks far outweigh any putative benefits. There are literally hundreds of mammalian viruses out in nature that pose zero risk to humans but which could be modified by these procedures to generate novel pandemic diseases with which the human immune system has had no prior experience.
  - reeaper 3y ago
    [flagged]
  - freitzkriesler2 3y ago
    Great comment but the down d00ters can't handle using common sense and will happily swallow any narrative told to them by talking heads.

baja_blast 3y ago

> Probably not engineered or lab-adapted. Despite having a novel furin cleavage site in the exact location as stated in a grant proposal, a furin cleavage site that happens to make the virus extremely infectious towards humans all while leaving no trace of how it adapted this feature. This seems to me more like a desperate attempt to avoid any regulations or attention drawn to this reckless research conducted all over the world!

lamontcg 3y ago
A PRRA furin cleavage site that was a previously unknown sequence and not something that a scientist would have copied off some other virus.
- BasedAnon 3y ago
  But one that could definitely emerge via gain of function.
  - lamontcg 3y ago
    No, it is amazingly unlikely that you'd see an insertion like that arise through some kind of random serial passage. In nature that happens by recombination which takes many millions of infections to emerge. In the lab you are just replicating that process by serial passage through animals where you might have a dozen animals serially infected. And the chances are probably lower because it is less likely the lab animals would wind up coinfected with another virus that would act as the source material. "Gain of function" research isn't magic.