3 ms·
Could someone clarify, does gene therapy cause a permanent gene mutation that can be passed on to offspring?
by aetherspawn 3y ago
Could someone clarify, does gene therapy cause a permanent gene mutation that can be passed on to offspring?
- inciampati 3y agoIt could. This is administered via an AAV rh74 vector, an adenovirus isolated from Rhesus monkeys. There is nothing stopping it from getting into the germ line. Notably, this effect may be primarily seen in males, as gametogenesis (cell divisions leading to sperm/eggs) is ongoing throughout life, in contrast to females where gametogenesis has completed at birth.