4 ms·

What's considered excess for Vitamin D?

jodrellblank 3y ago
UK NHS page says: "If you choose to take vitamin D supplements, 10 micrograms a day will be enough for most people." "Do not take more than 100 micrograms (4,000 IU) of vitamin D a day as it could be harmful. This applies to adults, including pregnant and breastfeeding women and the elderly, and children aged 11 to 17 years." https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/ https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-...
- Aerroon 3y ago
  The problem with vitamin D is that there's a lot of wrong information. It's because of this[0]: >A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L. Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L. >The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality 10 mcg = 400 IU. It's based on the previous (erroneous) daily recommended intake of 20 mcg per day. Also, if you look at how much vitamin D you get from sunlight then [1]: >A minimum erythema dose (1 MED) amounts to about 30 minutes midsummer midday sun exposure in Oslo (=20 mJ/cm2). Such an exposure given to the whole skin surface is equivalent to taking between 10,000 and 20,000 IU vitamin D orally, i.e. as much as 250-500 μg vitamin D, a similar amount as that obtained when consuming 200-375 mL of cod liver oil It makes me wonder if health authorities use a dart board to set recommended amounts for vitamins. But hey, at least they're finally changing things and 4000 IU (100 mcg) seems reasonable. I'm just wondering how they justified keeping recommendations at 10-20 mcg a day when the sunlight study says you can get 250-500 mcg in 30 minutes. Edit: I believe it's 30 minutes of midday sun. You're going to get a lot less vitamin D at other times of the day. [0] https://pubmed.ncbi.nlm.nih.gov/28768407 https://pubmed.ncbi.nlm.nih.gov/28768407 [1] https://pubmed.ncbi.nlm.nih.gov/19667143/ https://pubmed.ncbi.nlm.nih.gov/19667143/
  - cpill 3y ago
    I'm on 10k IU / day and have been for a couple of years now (my specialist prescribed it for me as part of Anti-MAP treatment for Crohn's Disease). He found a high correlation between patients that took high doses of vitamin D and recovery vs those that didn't (But he didn't give me a paper to read on it unfortunately)
    - ta988 3y ago
      You may want to get a chest xray to check for aortic calcification at some point.
  - westurner 3y ago
    > is equivalent to How does 30m exposure compare to a full workday in the sun? Does it scale up to a limit? What are the serum correlates to these dimensional studies? def gridsearch(person, intake={vitamin_d, vitamin_k, calcium, fiber})
    - Aerroon 3y ago
      I don't know. But it is my understanding that how high up in the sky the sun is matters a lot. Ie 5 pm sun is going to be a lot less effective than midday sun, because UV-B light has to go through more of the atmosphere. >Does it scale up to a limit? Yes, because sunlight only really makes a precursor to vitamin D. Ie you can't overdose on vitamin D from sunlight.
      - westurner 3y ago
        Prompt: generate a dataframe that lists: the amount of sunlight exposure by time, given the UV index, that corresponds to a given dose of Vitamin D in IUs, and milligrams (for each and/or an average patient profile) How much vitamin D supplementation results in the same serum level as sunlight exposure?
  - Mistletoe 3y ago
    Your skin automatically adjusts and “turns off” the vitamin D you get from sun when you have enough. > You cannot get too much vitamin D from sunshine because your skin limits the amount of vitamin D it makes. >https://ods.od.nih.gov/factsheets/VitaminD-Consumer https://ods.od.nih.gov/factsheets/VitaminD-Consumer I was once at a dinner sitting at the table with the head of the USA office of supplements and asked him how much Vitamin D one should take and he said “Get sunshine.”

UK NHS page says: "If you choose to take vitamin D supplements, 10 micrograms a day will be enough for most people." "Do not take more than 100 micrograms (4,000 IU) of vitamin D a day as it could be harmful. This applies to adults, including pregnant and breastfeeding women and the elderly, and children aged 11 to 17 years." https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-d/ https://www.nhs.uk/conditions/vitamins-and-minerals/vitamin-...

Aerroon 3y ago
The problem with vitamin D is that there's a lot of wrong information. It's because of this[0]: >A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L. Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L. >The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality 10 mcg = 400 IU. It's based on the previous (erroneous) daily recommended intake of 20 mcg per day. Also, if you look at how much vitamin D you get from sunlight then [1]: >A minimum erythema dose (1 MED) amounts to about 30 minutes midsummer midday sun exposure in Oslo (=20 mJ/cm2). Such an exposure given to the whole skin surface is equivalent to taking between 10,000 and 20,000 IU vitamin D orally, i.e. as much as 250-500 μg vitamin D, a similar amount as that obtained when consuming 200-375 mL of cod liver oil It makes me wonder if health authorities use a dart board to set recommended amounts for vitamins. But hey, at least they're finally changing things and 4000 IU (100 mcg) seems reasonable. I'm just wondering how they justified keeping recommendations at 10-20 mcg a day when the sunlight study says you can get 250-500 mcg in 30 minutes. Edit: I believe it's 30 minutes of midday sun. You're going to get a lot less vitamin D at other times of the day. [0] https://pubmed.ncbi.nlm.nih.gov/28768407 https://pubmed.ncbi.nlm.nih.gov/28768407 [1] https://pubmed.ncbi.nlm.nih.gov/19667143/ https://pubmed.ncbi.nlm.nih.gov/19667143/
- cpill 3y ago
  I'm on 10k IU / day and have been for a couple of years now (my specialist prescribed it for me as part of Anti-MAP treatment for Crohn's Disease). He found a high correlation between patients that took high doses of vitamin D and recovery vs those that didn't (But he didn't give me a paper to read on it unfortunately)
  - ta988 3y ago
    You may want to get a chest xray to check for aortic calcification at some point.
- westurner 3y ago
  > is equivalent to How does 30m exposure compare to a full workday in the sun? Does it scale up to a limit? What are the serum correlates to these dimensional studies? def gridsearch(person, intake={vitamin_d, vitamin_k, calcium, fiber})
  - Aerroon 3y ago
    I don't know. But it is my understanding that how high up in the sky the sun is matters a lot. Ie 5 pm sun is going to be a lot less effective than midday sun, because UV-B light has to go through more of the atmosphere. >Does it scale up to a limit? Yes, because sunlight only really makes a precursor to vitamin D. Ie you can't overdose on vitamin D from sunlight.
    - westurner 3y ago
      Prompt: generate a dataframe that lists: the amount of sunlight exposure by time, given the UV index, that corresponds to a given dose of Vitamin D in IUs, and milligrams (for each and/or an average patient profile) How much vitamin D supplementation results in the same serum level as sunlight exposure?
- Mistletoe 3y ago
  Your skin automatically adjusts and “turns off” the vitamin D you get from sun when you have enough. > You cannot get too much vitamin D from sunshine because your skin limits the amount of vitamin D it makes. >https://ods.od.nih.gov/factsheets/VitaminD-Consumer https://ods.od.nih.gov/factsheets/VitaminD-Consumer I was once at a dinner sitting at the table with the head of the USA office of supplements and asked him how much Vitamin D one should take and he said “Get sunshine.”