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Recent studies suggest that taking vitamin K supplements does not help to prevent calcium build up in heart valve. https://www.heart.org/en/news/2022/04/25/des

• snapplebobapple 3y ago
  I don't believe they controlled for vitamin D status. The line has always been you need k and d in sufficient levels to get calcium to the right place so I'm not surprised that one or the other causes problems (although I do really want to see someone redo this with people with clinically validated moderate vitamin d levels).
  • codersfocus 3y ago
    The linked article states they prescribed both vit d and k.
    • snapplebobapple 3y ago
      That's not the same as controlling for vitamin d because people's blood levels vary wildly even with supplementation. To control for vitamin d level you would need to blood test for it and supplement until the blood level is between 20 ng/ml and 50 ng/ml, ideally around 30. Depending on how they were supplementing blood levels could be way too low still (especially for obese people) or way too high with likely different effects on the outcome here.
• raylad 3y ago
  The dosage of vitamin K was probably much too low. In Japan K2 is dosed at 45mg (not mcg) per day, which was found to be the minimum effective dose for osteoporosis. A reasonable dose for coronary calcium is probably at least 5mg or more, a far higher dose than the 750mcg they used in the study. References: https://pubmed.ncbi.nlm.nih.gov/24841104/ https://pubmed.ncbi.nlm.nih.gov/24841104/ https://pubmed.ncbi.nlm.nih.gov/11886767/ https://pubmed.ncbi.nlm.nih.gov/11886767/