Yes but "the dose makes the poison". Unless you're showing direct cumulative, irreparable damage, then it is not possible to extrapolate by poisoning something

Yes but "the dose makes the poison". Unless you're showing direct cumulative, irreparable damage, then it is not possible to extrapolate by poisoning something with a large amount of chemical that the small amount is just as bad. Pure water - i.e. Milli-Q ultrapure water - is in fact a toxin in moderate quantities due to osmotic effects.