These sorts of studies have been performed before -- for example, in the human brain of ALS patients pre and post-mortem (albeit with histology rather than ligh

These sorts of studies have been performed before -- for example, in the human brain of ALS patients pre and post-mortem (albeit with histology rather than light sheet microscopy) [1] with a fairly sophisticated automated image processing pipeline [2]; or more broadly with a wider range of causes of death [3]. There's even an "open brain bank" for the resulting data -- [4] -- and it looks to be rather well populated in the other species section [5]. I wonder if the authors of this work (who have produced beautiful data!) will be contributing to it -- I can't find a link to the atlases themselves. Remember, with MR at thermal equilibrium the total amount of signal you can have is, all other things equal, proportional to the square root of scan time – their acquisition time is 245 hours! [1] https://bmcneurosci.biomedcentral.com/articles/10.1186/s12868-018-0416-1 https://bmcneurosci.biomedcentral.com/articles/10.1186/s1286... [2] https://www.sciencedirect.com/science/article/pii/S1053811922008473 https://www.sciencedirect.com/science/article/pii/S105381192... [3] https://www.sciencedirect.com/science/article/pii/S1053811917304706 https://www.sciencedirect.com/science/article/pii/S105381191... [4] https://elifesciences.org/articles/73153 https://elifesciences.org/articles/73153 [5] https://open.win.ox.ac.uk/DigitalBrainBank/ https://open.win.ox.ac.uk/DigitalBrainBank/