This is going to depend on the mode of action of the active agent, and the coordinating molecules and proteins that lead to presence of the active agent affecti

This is going to depend on the mode of action of the active agent, and the coordinating molecules and proteins that lead to presence of the active agent affecting expression of these specific genes. Let's say the small molecule binds a cell-surface receptor causing a cascade that prompts downregulation or upregulation of a transcription factor. The cell-surface receptor binding domain may differ enough between various mammal species that it has less, or more, of an effect in some species than others, and no effect at all in other species. I think the important part to assume there is something here that probably affects humans in a similar way is the previous linkage of soy oil to obesity and diabetes in humans.