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Soybean oil decreases oxytocin levels in hypothalamus in mice (2020)
- LatteLazy 3y agoChange in gene expression != change in genes.
- slater 3y ago[flagged]
- Sunspark 3y agoIn this specific case, I would assume that the finding would apply to pretty much all mammals. Unless of course, the mice organs convert it to a different chemical compound than us and it's that other one that is doing the damage.
- anonymouskimmer 3y agoThis is going to depend on the mode of action of the active agent, and the coordinating molecules and proteins that lead to presence of the active agent affecting expression of these specific genes. Let's say the small molecule binds a cell-surface receptor causing a cascade that prompts downregulation or upregulation of a transcription factor. The cell-surface receptor binding domain may differ enough between various mammal species that it has less, or more, of an effect in some species than others, and no effect at all in other species. I think the important part to assume there is something here that probably affects humans in a similar way is the previous linkage of soy oil to obesity and diabetes in humans.
- FreshStart 3y agoYeah, we had cold and hot summers before, I'm not convinced. This is another attack on the crackpot comunity.. In all seriousness it depends on the simalirity of the organs and chemical cycles modeled from mice and men. The bloodbrain barrier and neurons are very similar. And for alot of other systems there are mice bred specifically to recreate human disease simulacra. There are differences and they can be cited when catching a erroneous experiment. https://pubmed.ncbi.nlm.nih.gov/14978070/ https://pubmed.ncbi.nlm.nih.gov/14978070/ Just hinting at the difference as a catch all is insufficient.
- Maxion 3y ago[flagged]
- slater 3y ago(it's a fairly common trope on HN, any time there's a breathless clickbait-y title about some research results, there's a high chance it was tested only in mice, results for humans may vary, etc. etc.)
- wiml 3y agotldr: soy oil, and not other oils or other soy products, cause some changes in gene expression in mice that could be linked to various diseases (not "genetic changes". this is a badly written article)
- anonymouskimmer 3y agoThis oil probably wasn't cooked, or used for frying. If they can isolate the active ingredient it would be worthwhile checking the heat stability of said ingredient. Maybe soy oil needs to be reduced in uncooked form (such as for salad or dipping oils) but is fine to use for frying. Maybe it's problematic regardless. If this effect is also present in humans, I wonder whether people who have been using soy oil for many generations have genetically or epigenetically adapted to moderate or eliminate this effect.
- _xnmw 3y agoCenturies later after Pax Americana ends historians will be talking about soybean oil like we talk about lead pipes in Rome.
- fransje26 3y agoYou can also add corn syrup in the mix for good measure..
- Spivak 3y agoWhy are people so weird about corn syrup? If you're fine with other forms of refined sugar you should be fine with corn syrup and vice versa. People make what is essentially corn syrup in the form of invert sugar from sugar cane.
- tekla 3y agoProbably ignorance of chemistry. I always have a fun time when people demonize fructose, and then I point out its completely natural organic fruit sugar. (I mention natural and organic in the colloquial way, not the actual definition)
- dsabanin 3y agoFrom https://en.wikipedia.org/wiki/Fructolysis https://en.wikipedia.org/wiki/Fructolysis: > Unlike glucose, which is directly metabolized widely in the body, fructose is almost entirely metabolized in the liver in humans, where it is directed toward replenishment of liver glycogen and triglyceride synthesis. They are not the same.
- francisofascii 3y agoAgree that corn syrup is not much worse and essentially the same as refined sugar, but they are both bad in large amounts and added everywhere to our foods.
- zenapollo 3y ago
- pleb_nz 3y agoIm not sure about where Soy oil fits in, but there seems to be growing evidence that oils made from seeds, often called vegetable oils, are in fact quite bad for you especially when used for cooking.
- coder4life 3y agoWalnut, almond, sunflower oil are not bad for you. They're expensive. Vegetable oil as you know it and it's sold is soybean oil. Maybe another cheap oilseed like canola or corn, but that's it because it's cheap.
- 7speter 3y agoPeanut oil is so expensive/valuable that the peanut oil is usually extracted and replaced with palm oil,which has its own environmental issues, before the rest of the peanut is used to make peanut butter.
- sfjailbird 3y agoSunflower oil is in the same category as soybean and canola oil, industrially extracted from seeds and consisting of the type of omega-6 that in any but the most miniscule amounts are harmful in a number of ways, and a poor source of metabolic energy to boot. Walnut, almond, etc., are good for us, but in small amounts, and don't keep well or withstand heat, all of which make them unsuitable for cooking. We need to go back to saturated and monounsaturated fats, they are fine, and not actively harmful like the garbage waste products that are 'vegetable oils'.
- taffer 3y ago> consisting of the type of omega-6 that in any but the most miniscule amounts are harmful in a number of ways, and a poor source of metabolic energy to boot. I have been hearing this for years, but I have never found a reputable scientific source for this claim about omega-6 and omega-3. All I can find are sketchy websites trying to sell something.
- nimbleal 3y ago
- uejfiweun 3y agoWhy is it that it's only sketchy websites like this that report on soybean oil and other seed oils? Surely if it were such a big deal, reputable news outlets would have picked up the story, no? What's going on here? Is the whole thing bullshit? Or is big seed oil covering it up?
- sfjailbird 3y agoI think you are out of the loop. You say 'big seed oil' like it's a joke, but that's certainly a thing and a major lobby. There's a reason margerine was promoted as the healthy choice for decades (without 'reputable news sources' picking up on that it is, in fact, poison, and now illegal in most countries).
- birdyrooster 3y agoIf the lobby is so powerful then why is it illegal in most countries?
- bigbillheck 3y ago> now illegal in most countries This is news to me, would you mind providing a citation or two?
- itairall 3y agoI always assume these articles are for out of shape people checking their phones while eating McDonalds french fries pretending to worry about their health or really in shape people that only eat organic quail eggs. I just really doubt that seed oils vs some other fat would be my downfall.
- anonymouskimmer 3y agoScience Daily reported on it too: https://www.sciencedaily.com/releases/2020/01/200117080827.htm https://www.sciencedaily.com/releases/2020/01/200117080827.h... And of course the Endocrine society did: https://endocrinenews.endocrine.org/eureka-2020-part-i-top-endocrine-science-from-endocrinology-editors/ https://endocrinenews.endocrine.org/eureka-2020-part-i-top-e... A possible reason for "reputable" news outlets to not report on this is that the link between soybean oil and diabetes/obesity was already known. This paper demonstrates some specific gene regulation effects, but other than the oxytocin-insulin link any other effects are more speculatory.
- coder4life 3y agoThis information is a decade old. The answer is don't let anyone else dictate what goes in your mouth, and you are, and they'll give you soybean or rapeseed (oops, canola). It's in every fryer in the land, and you lie to yourself to think otherwise.
- throwaway81523 3y agoThe oil is soybean oil and other than that clickbit, the article is actually interesting, but is from 2020 so the link should be updated.
- blodkorv 3y agoI really dont see how soybean oil in by itself causes obesity as is stated in the article. If you don exceed your daily caloric intace then you wont gain weight no matter what kind of oil you eat.
- lm28469 3y agoProbably that part: > potentially impacting energy metabolism CICO is mostly true if you already have a balanced diet, if you eat 2000kcal of ultra processed food you'll have side effects you wouldn't have with a cleaner diet. The body is a fine tuned machine, it doesn't process 100kcal of sugar the same way it processed 100kcal of broccoli
- moi2388 3y agoWhilst that is true, in neither case will it extract the full kcal, since that was calculated by completely burning the food (in a calorimeter). If you burn more than 100kcal you will not gain weight no matter what. You might still get fatter, but your total mass cannot increase if you burn more calories than you consume unless you violate conservation of energy.
- mariusor 3y agoI am so weirded out that almost nobody seems to acknowledge that calorie numbers have no actual meaning with the way digestion processes food in a human body. Relying on food consumption advice that's based on calorie numbers and math is invariably wrong, the only way it might happen to have any meaningful impact is because low numbers mean lower overall quantities. Also the way calories are "counted" in exercise is absolutely bogus for individuals because it rarely takes into account their physiology and basically uses made up numbers of various exercise types.
- tekla 3y agoCreating mass out of nothing is literally impossible.
- hsjqllzlfkf 3y agoIt's time to bring back Olestra. You heard it here first.
- IntrepidWorm 3y ago[flagged]
- jcarrano 3y agoIn a couple of years they will realize that cooking in animal fat was the healthier choice all along.
- datavirtue 3y agoNot for the animals.
- arghandugh 3y agoPlease don’t post seed oil truther discourse here.
- mensetmanusman 3y agoMaybe we will pay attention to lifestyles when obesity reaches 90% of the population. It’s only half right now.