Is it worth putting maximum effort into your job if it causes depression and burnout (making you less effective at your job), makes you sick because of stress (

Is it worth putting maximum effort into your job if it causes depression and burnout (making you less effective at your job), makes you sick because of stress (making you less effective at your job), ruins your marriage (making you less effective at your job), and gives you less time to educate your kids (making the next generation less effective at their jobs)? Human effort is burstable, sort of, but for most people it's taxing to burst up to maximum effort. Apparently this isn't true for Carmack, but I have doubts.