3 ms·
Surely it would be like other antivirals(paxlovid) which have shown to help certain long Covid phenotypes? I.e. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC95
by thenerdhead 3y ago
Surely it would be like other antivirals(paxlovid) which have shown to help certain long Covid phenotypes?
I.e. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537824/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9537824/
> Though not indicated for the treatment of PASC, the treating physician felt that her prolonged nasopharyngeal antigen positivity warranted the treatment. Indeed, the patient’s PASC symptoms fully resolved 3 weeks after completing antiviral treatment
- retrac 3y agoIt's not clear it's acting as an antiviral, in the classic sense of directly interfering with the virus, by directly bonding with and neutralizing viral proteins, or supplying lookalike proteins for the cells to make defective viral particles with. Metformin affects glucose metabolism. It may be similar to how metformin seems to help with HIV infection; an immune cell infected with HIV goes into metabolic overdrive as it starts producing virus. Metformin seems to block that boosting mechanism through its effect on glucose, preferentially on the most over-driven cells. A similar story with certain glucose-fed cancers, which metformin is also used in treating.
- thenerdhead 3y agoYeah that is fair. I think it is very uplifting that even though we don’t know the mechanism, it may be used for potential long Covid treatment