3 ms·
> Firstly, it is important to note that the drug was only tested in vitro using a single line of monkey kidney cells engineered to express human signaling lymph
by zimpenfish 3y ago
> Firstly, it is important to note that the drug was only tested in vitro using a single line of monkey kidney cells engineered to express human signaling lymphocytic activation molecule (SLAM), also known as CDw150, which is a receptor for the measles virus
> Also, ivermectin has not been tested in any pulmonary cell lines, which are critical for SARS-CoV-2 in humans
> Furthermore, these authors did not show whether the reduction seen in RNA levels of SARS-CoV-2 following treatment with ivermectin would indeed lead to decreased infectious virus titers.
> Importantly, the drug concentration used in the study (5 μM) to block SARS-CoV-2 was 35-fold higher than the one approved by the FDA for treatment of parasitic diseases
"demonstrated" is doing a lot of lifting in that abstract given those caveats (and there's several more pages of caveats and "could", "maybe", "might", "may" hedging after those.)