Yes. Most people bring it up because they have an interest in a specific study or result being wrong, which I suspect has trained people to be dubious of anyone

Yes. Most people bring it up because they have an interest in a specific study or result being wrong, which I suspect has trained people to be dubious of anyone questioning The Science. And some people treat it as a quasi belief system, which makes sense, with precepts like 'the world is deterministic, causes precede effects' and so on. You could do worse. But they aren't scientists and they don't generally grok that science is an activity whose output is sometimes useful models and not 'Truth'. My mental model here is that you thus get people who trust in science as a paradigm, who then see doubt or skepticism as aimed against the whole edifice that is part of their fundamental understanding of the world, resulting in discomfort and leading to expected results. In other words pretty normal stuff that resembles when you come across an argument whose implications are opposed to your principles, that you suspect of trickery, but lack the rhetoric to dismantle yourself.