The study dosing was 1mg/day, compared to the standard dose as a laxative of 2mg. "In this study, we used a low dose of prucalopride (1 mg as opposed to the li

The study dosing was 1mg/day, compared to the standard dose as a laxative of 2mg. "In this study, we used a low dose of prucalopride (1 mg as opposed to the licenced dose of 2 mg) to reduce the risk of side effects. At this time, we currently lack information about the optimal dose of prucalopride needed for occupancy of brain 5-HT4 receptors, although data from our previous reports indicate that 1mg is sufficient to demonstrate pro-cognitive potential."