5 ms·

Too bad it's also a laxative.

cvccvroomvroom 3y ago
Magnesium is too, to a degree. With age, this is often a good property. There are plenty of opioid analogues to decrease it safely.
- StrangeATractor 3y ago
  Mag isn't too bad, I believe you also get acclimated to it (haven't taken it in a while). IME it's not much different from having a fiber-heavy diet.
- tpm 3y ago
  With magnesium it's more the specific salts that are laxative. Like the oxide which is both a laxative and has a low bioavailability. Citrate in huge doses is used as a laxative too. On the other hand, I have good experience with the orotate. Lactate and gluconate should be good too.
  - scns 3y ago
    Bisglycinate is supposed to have the highest bioavailability.
    - carlmr 3y ago
      And IME zero laxative effects. Citrate in normal doses is also okay
  - TheSpiceIsLife 3y ago
    Magnesium amino acid chelate is best for most, especially magnesium di-glycinate.
- freehorse 3y ago
  Magnesium supplements have laxative effects as long as they are not absorbed. More bioavailable forms of magnesium do not exhibit laxative effects in normal dosages.
- laeri 3y ago
  I think magnesium can also lead to other issues related to cardiac arrythms. I have no direct source to point to however.
msla 3y ago
So's Lexapro for some people. (Me. I'm some people.)
- mtlmtlmtlmtl 3y ago
  That's funny, the main side effect for me was inability to urinate.
  - fyloraspit 3y ago
    I've had both feelings from MDMA. Urgent need for #2 on come up. Complete inability to perform #1 even though busting at peak. Maybe it's a serotonin thing
campers 3y ago
The study dosing was 1mg/day, compared to the standard dose as a laxative of 2mg. "In this study, we used a low dose of prucalopride (1 mg as opposed to the licenced dose of 2 mg) to reduce the risk of side effects. At this time, we currently lack information about the optimal dose of prucalopride needed for occupancy of brain 5-HT4 receptors, although data from our previous reports indicate that 1mg is sufficient to demonstrate pro-cognitive potential."
Detrytus 3y ago
Clears shit from both your body and your mind, at the same time :)
scotty79 3y ago
I'm not quite sure if laxative is the correct description of this drug, even though it's official one. It is used for treatment of constipation in cases where laxatives don't help. I'm not sure if it has any similar effects in non-constipated people as other laxatives have.

Magnesium is too, to a degree. With age, this is often a good property. There are plenty of opioid analogues to decrease it safely.

StrangeATractor 3y ago
Mag isn't too bad, I believe you also get acclimated to it (haven't taken it in a while). IME it's not much different from having a fiber-heavy diet.
tpm 3y ago
With magnesium it's more the specific salts that are laxative. Like the oxide which is both a laxative and has a low bioavailability. Citrate in huge doses is used as a laxative too. On the other hand, I have good experience with the orotate. Lactate and gluconate should be good too.
- scns 3y ago
  Bisglycinate is supposed to have the highest bioavailability.
  - carlmr 3y ago
    And IME zero laxative effects. Citrate in normal doses is also okay
- TheSpiceIsLife 3y ago
  Magnesium amino acid chelate is best for most, especially magnesium di-glycinate.
freehorse 3y ago
Magnesium supplements have laxative effects as long as they are not absorbed. More bioavailable forms of magnesium do not exhibit laxative effects in normal dosages.
laeri 3y ago
I think magnesium can also lead to other issues related to cardiac arrythms. I have no direct source to point to however.

msla 3y ago

So's Lexapro for some people. (Me. I'm some people.)

mtlmtlmtlmtl 3y ago
That's funny, the main side effect for me was inability to urinate.
- fyloraspit 3y ago
  I've had both feelings from MDMA. Urgent need for #2 on come up. Complete inability to perform #1 even though busting at peak. Maybe it's a serotonin thing

campers 3y ago

The study dosing was 1mg/day, compared to the standard dose as a laxative of 2mg. "In this study, we used a low dose of prucalopride (1 mg as opposed to the licenced dose of 2 mg) to reduce the risk of side effects. At this time, we currently lack information about the optimal dose of prucalopride needed for occupancy of brain 5-HT4 receptors, although data from our previous reports indicate that 1mg is sufficient to demonstrate pro-cognitive potential."

Detrytus 3y ago

Clears shit from both your body and your mind, at the same time :)

scotty79 3y ago

I'm not quite sure if laxative is the correct description of this drug, even though it's official one. It is used for treatment of constipation in cases where laxatives don't help. I'm not sure if it has any similar effects in non-constipated people as other laxatives have.