You generally want to use a region close to your users, so right off the bat, us-east-1 and us-east-2 are the obvious choices for most East Coast companies. If

You generally want to use a region close to your users, so right off the bat, us-east-1 and us-east-2 are the obvious choices for most East Coast companies. If I were starting a new project, I'd probably go us-east-2, but if your company has been on the cloud long enough, us-east-2 might not have existed when your foundational infrastructure was created. And for most companies, going multi-region is an expensive, difficult proposition that might not be worth it. Plus, as others have noted, there are critical AWS services in their control plan that only run in us-east-1 behind the scenes. So you're kind of out of luck.