Or genetic mutations (which also may interact with specific lifestyle factors). At least one such mutation was identified in an Italian family that is seemingly

Or genetic mutations (which also may interact with specific lifestyle factors). At least one such mutation was identified in an Italian family that is seemingly immune to atherosclerosis [1], and the "blue zone" populations tend to be relatively small and isolated (at least before the industrial revolution). [1] https://en.wikipedia.org/wiki/ApoA-1_Milano https://en.wikipedia.org/wiki/ApoA-1_Milano