3 ms·

> That said, I'd absolutely recommend sugar over many other available sweeteners. I sure wouldn't. Many of the classic, non-nutritive sweeteners like sucralose

> That said, I'd absolutely recommend sugar over many other available sweeteners. I sure wouldn't. Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest. Even at heroic doses tens of thousands of times higher than what would be used normally, no significant health effects have been noted. In contrast, we have sucrose: a caloric carbohydrate that rapidly and reliably raises blood sugar, and due to its fructose content, has been linked to NAFLD. If nothing else, it's 'empty' caloric value, high palatability, popularity in beverages, and low cost (especially as the almost functionally identical HFCS) has without a doubt been a major contributor to the obesity epidemic. So sure, removing all added sweeteners ('natural' or otherwise) would be better, but a NNS is way, way better than sugar.

throwaway2037 3y ago
You seem knowledgeable about sucralose ("Splenda" in US commercial branding). Thank you to share. On Wiki, it says that sucralose is "genotoxic", but provides no further information. I read the genotoxic Wiki page -- sounds terrible. What am I missing? To be clear: This is not a scare post, rather "explain it to me like I am a 5 year old"! When I Google <<sucralose genotoxic>>, most of the results are untrustworthy, click-bait news sources.
- vhcr 3y ago
  The genotoxic edit was added by an IP editor citing an in-vitro study, I wouldn't pay much attention to it, you can find higher quality references on the article, for example this one: https://www.sciencedirect.com/science/article/pii/S0278691517302818 https://www.sciencedirect.com/science/article/pii/S027869151...
  - throwaway2037 3y ago
    Nice post. Thanks for the info. I was bothered that "genotoxic" didn't have a reference. For other readers, I didn't know what "in-vitro study" meant. Google tells me: In vitro is Latin for “in glass.” It describes medical procedures, tests, and experiments that researchers perform outside of a living organism. An in vitro study occurs in a controlled environment, such as a test tube or petri dish.
diydsp 3y ago
> Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest. ..until last week: https://duckduckgo.com/?q=sucralose+cancer https://duckduckgo.com/?q=sucralose+cancer
- JibberMeTimbers 3y ago
  Also: https://www.splenda.com/blog/splenda-brand-statement-on-recent-study-on-sucralose-6-acetate/ https://www.splenda.com/blog/splenda-brand-statement-on-rece...

throwaway2037 3y ago

You seem knowledgeable about sucralose ("Splenda" in US commercial branding). Thank you to share. On Wiki, it says that sucralose is "genotoxic", but provides no further information. I read the genotoxic Wiki page -- sounds terrible. What am I missing? To be clear: This is not a scare post, rather "explain it to me like I am a 5 year old"! When I Google <<sucralose genotoxic>>, most of the results are untrustworthy, click-bait news sources.

vhcr 3y ago
The genotoxic edit was added by an IP editor citing an in-vitro study, I wouldn't pay much attention to it, you can find higher quality references on the article, for example this one: https://www.sciencedirect.com/science/article/pii/S0278691517302818 https://www.sciencedirect.com/science/article/pii/S027869151...
- throwaway2037 3y ago
  Nice post. Thanks for the info. I was bothered that "genotoxic" didn't have a reference. For other readers, I didn't know what "in-vitro study" meant. Google tells me: In vitro is Latin for “in glass.” It describes medical procedures, tests, and experiments that researchers perform outside of a living organism. An in vitro study occurs in a controlled environment, such as a test tube or petri dish.

diydsp 3y ago

> Many of the classic, non-nutritive sweeteners like sucralose have been tested more thoroughly than almost any substance we ingest. ..until last week: https://duckduckgo.com/?q=sucralose+cancer https://duckduckgo.com/?q=sucralose+cancer

JibberMeTimbers 3y ago
Also: https://www.splenda.com/blog/splenda-brand-statement-on-recent-study-on-sucralose-6-acetate/ https://www.splenda.com/blog/splenda-brand-statement-on-rece...