Sample size is just one factor. For example, if you are interested in heights and you measure six people and they are all over 10 feet tall, you can go ahead an

Sample size is just one factor. For example, if you are interested in heights and you measure six people and they are all over 10 feet tall, you can go ahead and conclude they are from a group with different height distribution than the rest of humans. Pretending that these papers of “wow, we found a substance that when given to ten people in a cancer group with a 99% six month lethality and three survived more than two years” contribute nothing is a weird belief. Penicillin was what n = 1.