5 ms·

In the study mice were given 1000 mg taurine per kg body weight per day. In comparison a typical taurine supplement for humans is 1000 mg total. IOW they gave

In the study mice were given 1000 mg taurine per kg body weight per day. In comparison a typical taurine supplement for humans is 1000 mg total. IOW they gave the mice a dose of taurine that, proportionally, i'd be unwilling to take.

rale00 3y ago
You don't directly convert dosage across species like that. The dosage they tested on monkeys was 250mg/kg, and the human equivalent would be less than that.
- A_D_E_P_T 3y ago
  The basic formula from mouse to human is (X mg * (3/37)) = human equivalent dose in mg/kg. In this case (1000mg * 3/37)) comes out to 81mg/kg. So, if you weigh 80kg, it comes out to 6.48 grams per day. That's a lot of taurine, but not really a crazy amount. Easy enough to consume.
  - codeflo 3y ago
    Is there a precise biological explanation for that factor, e.g. metabolism rate or something?
    - A_D_E_P_T 3y ago
      > oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function The equation is from here: https://pubmed.ncbi.nlm.nih.gov/17942826/ https://pubmed.ncbi.nlm.nih.gov/17942826/ For what it's worth, the rat equation is (X mg * (6/37)) Keep in mind that it's a loose/general guideline. Basically a starting point. But usually a quite accurate one.
    - hooo 3y ago
      When my son had cancer, many of the medication dosages were based on body surface area. Maybe it is similar to that. https://reference.medscape.com/calculator/692/body-surface-area-based-dosing https://reference.medscape.com/calculator/692/body-surface-a...
  - Turing_Machine 3y ago
    I see that Amazon sells 1 gram capsules of taurine (several vendors). So, yeah, not too difficult to consume. One brand I saw is about $0.08/gram, so it wouldn't be overly financially burdensome, either.
    - dreamcompiler 3y ago
      IMO anything you buy from Amazon that goes into your body should be considered at best fraudulent and at worst toxic until proven otherwise.
0cf8612b2e1e 3y ago
For what it’s worth, Wikipedia is currently referencing a 2009 study which had previously tested 1000mg/kg in humans.
- PaulHoule 3y ago
  Really? For a 100kg human (me) that is 100g a day of taurine which is more than 3 ounces or this whole bottle https://www.amazon.com/NOW-Supplements-Taurine-Strength-Capsules/dp/B0019LRYD0/ https://www.amazon.com/NOW-Supplements-Taurine-Strength-Caps... and costs about $9. Seems like a lot. Contrast that to the claim that people should eat about 800mg/kg a day of protein overall https://www.sclhealth.org/blog/2019/07/how-much-protein-is-simply-too-much/ https://www.sclhealth.org/blog/2019/07/how-much-protein-is-s...
  - 0cf8612b2e1e 3y ago
    Not saying it is a good idea, but based on that one study I did not read, the amount is tolerable without acute symptoms.
AtlasBarfed 3y ago
1000 mg ... you mean a gram :-) ?
- iopq 3y ago
  he meant 0.001 kg
  - krisoft 3y ago
    Or about 5e-34 solar mass, which is the only natural way to measure your intakes :)
stefs 3y ago
> Serious adverse effects have not been reported with taurine supplementation.[24] The highest dose used in a human trial was 10 grams per day for 6 months, and the longest human trial was 12 months and used a dose of 0.5–1.5 grams per day. Based on the available evidence, it’s suggested that 3 grams per day can be consumed indefinitely without risk of side effects.[24] https://examine.com/supplements/taurine/ https://examine.com/supplements/taurine/

rale00 3y ago

You don't directly convert dosage across species like that. The dosage they tested on monkeys was 250mg/kg, and the human equivalent would be less than that.

A_D_E_P_T 3y ago
The basic formula from mouse to human is (X mg * (3/37)) = human equivalent dose in mg/kg. In this case (1000mg * 3/37)) comes out to 81mg/kg. So, if you weigh 80kg, it comes out to 6.48 grams per day. That's a lot of taurine, but not really a crazy amount. Easy enough to consume.
- codeflo 3y ago
  Is there a precise biological explanation for that factor, e.g. metabolism rate or something?
  - A_D_E_P_T 3y ago
    > oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function The equation is from here: https://pubmed.ncbi.nlm.nih.gov/17942826/ https://pubmed.ncbi.nlm.nih.gov/17942826/ For what it's worth, the rat equation is (X mg * (6/37)) Keep in mind that it's a loose/general guideline. Basically a starting point. But usually a quite accurate one.
  - hooo 3y ago
    When my son had cancer, many of the medication dosages were based on body surface area. Maybe it is similar to that. https://reference.medscape.com/calculator/692/body-surface-area-based-dosing https://reference.medscape.com/calculator/692/body-surface-a...
- Turing_Machine 3y ago
  I see that Amazon sells 1 gram capsules of taurine (several vendors). So, yeah, not too difficult to consume. One brand I saw is about $0.08/gram, so it wouldn't be overly financially burdensome, either.
  - dreamcompiler 3y ago
    IMO anything you buy from Amazon that goes into your body should be considered at best fraudulent and at worst toxic until proven otherwise.

0cf8612b2e1e 3y ago

For what it’s worth, Wikipedia is currently referencing a 2009 study which had previously tested 1000mg/kg in humans.

PaulHoule 3y ago
Really? For a 100kg human (me) that is 100g a day of taurine which is more than 3 ounces or this whole bottle https://www.amazon.com/NOW-Supplements-Taurine-Strength-Capsules/dp/B0019LRYD0/ https://www.amazon.com/NOW-Supplements-Taurine-Strength-Caps... and costs about $9. Seems like a lot. Contrast that to the claim that people should eat about 800mg/kg a day of protein overall https://www.sclhealth.org/blog/2019/07/how-much-protein-is-simply-too-much/ https://www.sclhealth.org/blog/2019/07/how-much-protein-is-s...
- 0cf8612b2e1e 3y ago
  Not saying it is a good idea, but based on that one study I did not read, the amount is tolerable without acute symptoms.

AtlasBarfed 3y ago

1000 mg ... you mean a gram :-) ?

iopq 3y ago
he meant 0.001 kg
- krisoft 3y ago
  Or about 5e-34 solar mass, which is the only natural way to measure your intakes :)

stefs 3y ago

> Serious adverse effects have not been reported with taurine supplementation.[24] The highest dose used in a human trial was 10 grams per day for 6 months, and the longest human trial was 12 months and used a dose of 0.5–1.5 grams per day. Based on the available evidence, it’s suggested that 3 grams per day can be consumed indefinitely without risk of side effects.[24] https://examine.com/supplements/taurine/ https://examine.com/supplements/taurine/