Well some of the solutions have been tried elsewhere. It's not hard to simulate "no stuff from the outside", that's not something you need to go to the south po

Well some of the solutions have been tried elsewhere. It's not hard to simulate "no stuff from the outside", that's not something you need to go to the south pole to do. There is an argument to be made for the disease vector thing, but even that would probably be cheaper to do in a completely closed loop system somewhere more hospitable.