6 ms·
TLDR; participants with cocaine history were administered caffeine IV. At high doses (300mg) they reported some mild euphoria, and a strange taste and/or smell
by engineer_22 3y ago
TLDR; participants with cocaine history were administered caffeine IV. At high doses (300mg) they reported some mild euphoria, and a strange taste and/or smell.
Ask HN: aside from caffeine, what is the drug of choice around here?
- bigdict 3y agoAI hype
- boredemployee 3y agometh and adderall
- deleted 3y ago[deleted]
- kenniskrag 3y agochocolate
- awestroke 3y agoArrogance
- sdwr 3y agoThat's the good stuff!
- thedrexster 3y agoLSD is my happy place -- and Adderall, but I've a prescription for that one!
- suslik 3y agoMicrodosing?
- deafpolygon 3y agocrypto laced with AI
- JLCarveth 3y agoI doubt you'll get too many serious replies, but as a Canadian my DoC is cannabis.
- cactusplant7374 3y agoketamine
- ycombinete 3y agoMethylphenidate
- mock-possum 3y agoI’ve settled upon: Caffeine at work, alcohol not at work, molly to party with friends, weed to party on my own.
- PKop 3y agoRunning, hiking, lifting
- themodelplumber 3y agoSerious? I pre & post all of those + bicycling. Whammy, huge difference, especially if you leverage e.g. the caffeine for mental work, or whatever else each chemical is good at. Had some funny experiments in there but would never go back to nothing. It doesn't make sense, especially if you don't have an addictive personality & any chemical risk is more likely associated with quitting beneficial chemicals than staying on them too long.
- nologic01 3y agoopen source utopia
- BenFeldman1930 3y agoBooks.
- hammock 3y ago> high doses (300mg) What's the equivalent of a 300mg IV dose in oral ingestion?
- engineer_22 3y agoPer article it's 4-5 shots of espresso. Apparently caffeine is absorbed quickly by the gut, so if you shoot it all down at once, you'd get similar results.
- deleted 3y ago[deleted]
- isoprophlex 3y agoweb3 projects not working out; schadenfreude in general; the smell of my own farts.
- willcipriano 3y agoAdrenochrome
- tasty_freeze 3y agoTHC containing gummies, once a week, for music enhancement before bed. Tangential details... The 2018 hemp farm bill allows products to have up to 0.3% THC, but it took years for people to realize that gummies are hefty enough that 0.3% means a gummy can have 10-20mg of THC. So, at the ripe age of 57 I finally tried THC. It was very frustrating because most of the good stuff I expected didn't happen: no euphoria, no munchies, no relaxation. I do get some of the negative things, like dry mouth. The one good thing I get is music enhancement, but only if I do it once a week or less (10-15mg). I've tried doing it more frequently and upping the dose to compensate, but nope: if I invoke the genie too frequently he refuses to come out of the bottle.
- zls 3y agoI’m surprised you do it before bed! I find that especially with edibles, using thc too close to bed makes me sleep deeply but wake up groggy. Typically I need an afternoon nap the next day. I believe thc fucks with REM. Food is totally unchanged for you? Wild! What about movies/tv?
- recursive_loops 3y agoI get very little effect from weed unless I take a huge amount, in which case I also feel miserable with "too much" symptoms. It just doesn't seem to work for some people
- tasty_freeze 3y agoYup, it isn't enhanced at all, and I don't get extra cravings. Although I gone up to 25mg while I was experimenting to find a dose that works best for me, my target is 10mg. Maybe that isn't enough to trigger munchies. Because the only thing I find it good for is music enhancement, I like to take a gummy around 9pm-10pm, then two hours later put on three albums with a particular kind of music, then hope that I get enhancement. If I'm feeling tired that day, though, I put it off because sucks to hit the sweet spot and then immediately fall asleep and not get to enjoy the music. By enhancement, I mean I experience pronounced stereo separation and deeper notes seem to be very resonant. Sometimes I get little floaty and feel like I'm suspended in zero gravity while I drift to the music. Because I do it only once a week, I don't notice any disruption of my sleep. EDIT: you asked about TV/movies. I don't watch them, so I don't know.
- uoaei 3y agoMushrooms
- ehPReth 3y agobenzodiazepines.
- zwieback 3y agoZungenwurst, can't get enough of it
- gpas 3y agoCaffeine, nicotine, thc and alcohol.
- deleted 3y ago[deleted]
- mtlmtlmtlmtl 3y agoLow dose dextro-amphetamine for ADHD in everyday life, weed for music and various other enjoyment, only occasionally. Alcohol and whatever nose-friendly stimulants are available for parties. Psychedelics at most annually(ideally 2C-B or (1p-)LSD, but I've tried a whole host of different ones) for deep contemplation and introspection. Watching my brother destroy his life with Heroin has kept me away from opioids for the most part, but I don't like the way they make me feel anyway.
- recursive_loops 3y agoOpioids are no joke for sure. If you have good self discipline and can limit yourself to one every 2 to 3 days, it can be amazing and safe. But it makes you feel really good and many people don't have the self control required, so I recommend staying away. If you develop a physical dependence, it is not pleasant to say the least.
- mtlmtlmtlmtl 3y agoI mean I've tried opioids, but they make me nauseous. And tired. And i specifically avoided trying really strong ones because yeah, I know I wouldn't be able to handle it. It took years of suffering even to be able to control my cannabis use...
- zeta0134 3y agoMusic. String ensembles are the best, choir is a close second. Rapid response, mild euphoria, no unpleasant side effects. Repeated exposure can induce fatigue, making it an excellent sleep aid.
- hoosieree 3y agoSuccessful debugging session euphoria.
- oramit 3y agoCaffeine pretty much every day, I can only have it in the mornings though or it interferes with sleep. Alcohol a few times a week, usually just one or two drinks. Now that i'm mid thirties the booze hits me much harder than before and hangovers are easy to get. Pot gummies on the weekend when I want to relax. I know quite a few heavy users who will smoke a couple joints then go do yardwork - crazy. If I have any i'm eating a heavy meal and playing video games. I sleep great with it. I started smoking cigars over the pandemic, only a couple times a month, you certainly get a nicotine buzz that is kind of nice. It is smelly though so I don't do it often and it's more for the ritual and relaxation than the buzz. Amyl nitrates for other recreation. Wow writing that all out makes me look like a degenerate :)
- deleted 3y ago[deleted]
- kayodelycaon 3y agoPersonally, prescription medications are great: legal, consistent, safe, and effective. Wellbutrin (NDRI) every morning. Helps with attention and alertness. It isn't classified as a stimulant, so I don't need to deal with the regulations around regular ADHD meds. It also helps with sexual dysfunction caused by other meds. Benzos for social events. Way better than alcohol. All of the chill and none of the impairment. :)
- zhynn 3y agokratom.
- zhynn 3y agoleverage.
- matheusmoreira 3y agoPrescription amphetamines.