2 ms·
The TK6 cells were exposed to 20 concentrations of sucralose-6-acetate (maximum 4.5489 mM or 2000 μg/ml) or 20 concentrations of sucralose (maximum 10 mM or 398
by refurb 3y ago
The TK6 cells were exposed to 20 concentrations of sucralose-6-acetate (maximum 4.5489 mM or 2000 μg/ml) or 20 concentrations of sucralose (maximum 10 mM or 3980 μg/ml)
If you look at the genotoxic Multiflow results (tables 3-4), the genotoxic signals only showed up at the highest concentrations (>300 ug/mL).
Peak concentrations of sucralose in blood after consumption is ~300 ng/mL, so about 1000x fold less.
Also note the paper showed non-mutagenicity in the bacterial reserve mutation test (Ames Test).
So the results are interesting, but I'm not sure how applicable they are to actual exposure in humans.
- brnaftr361 3y agoI like to think of it on the cell basis. All you need is to nick off a tumor suppressor gene and you're much closer to a cancerous cell. That tends to be how cancer proliferates, right? One bad cell and then a tumor, metastasis - cancer. If you consider it on a particle scale, there's 4.5x(10^23) particles/mL. That's about 15 particles per cell per mL, and there's 3^13 cells in the body. Some of which are protected, others susceptible. I'd take a risk, just not one for funky tasting sweets. Of course I don't do it for regular sweets, either, which possess their own dangers.