I often remark that it's so easy to fail to replicate any moderately complex experiment, so you really have to do a great job to be sure that it's actually inva

I often remark that it's so easy to fail to replicate any moderately complex experiment, so you really have to do a great job to be sure that it's actually invalid. Whether it's the chemistry, equipment, or animals (even yeast) involved there are so many variables that need to be controlled only an expert can do it. If you think that the Methodology and experimental setup will (or even could) be sufficient, you're in for a rude surprise. Now there's now so much low hanging fruit, that it might be possible for a few labs to just look at the most outrageous published experimental claims for replication. Especially, anything published in a prestigious journal or groups with lots of influence could be carefully examined, but of course you have to do a great job to get your negative results published... it's also worth mentioning that the reputational risks of doing this are not small. If you're already being pushed out of academia and love working for peanuts though?