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Psychopharmacology, Modafinil is a slow acting long lasting weak dopamine reuptake inhibitor, so it’s non addictive and you can try it and see how it affects yo

Psychopharmacology, Modafinil is a slow acting long lasting weak dopamine reuptake inhibitor, so it’s non addictive and you can try it and see how it affects you as a diagnostic and if it works you take it as a treatment. There are other meds like Low Dose Naltrexone (LDN) which are also quite safe and can help a lot with dopamine dysregulation. Another potential avenue is diet, quit all sugar including fruit. A small percentage of the population reacts particularly badly to non lactose sugars and you may be one of them. I think a common cause of ADHD is undiagnosed hEDS, especially if you’re in tech. The usual tests for hEDS has a extremely high false negative rate so it’s way more prevalent than commonly believed, I think a mild form occurs at a rate of around 2% within European populations. As medical research has improved the accepted prevalence has gone from 1/50K to 1/15K to 1/500 and I think there is still an additional order of magnitude to go when able to test for the mild forms. These 2% are prone to dopamine dysregulation / burnout / ME/CFS and Long Covid. You don’t have to be particularly hypermobile to have hEDS, and in men especially the mild forms can be barely perceptible and symptoms usually show up in other ways.

moltar 3y ago
Interesting. Do you have more information? Thank you.
- cjbgkagh 3y ago
  Sure; the book Stahl's Essential Psychopharmacology is quite approachable and goes in depth on treatment and effects of various disorders including ADHD. It’s not perfect but nothing is. The https://ldnresearchtrust.org https://ldnresearchtrust.org is probably the best source for LDN information. Sarah Wilson of ‘I quit sugar’ fame talks about her experiences in quitting sugar. She repeatedly acknowledges that while quitting sugar is beneficial for most people it is of particular benefit to a small percentage of the population that are most likely to have ADHD. Her N of 1 experimentation is really good and highly aplicable to those similarity impacted by sugar in a way that more general research is not. The 2% of undiagnosed hEDS is probably most easily found by looking at comorbidities (https://ohtwist.com/about-eds/comorbidities https://ohtwist.com/about-eds/comorbidities) which occur within families on an autosomal dominant basis. Due to the perceived rarity of hEDS people with the more common milder form are often classified as Hypermobility Spectrum Disorder (HSD) but follow up research has found no real difference between hEDS and HSD, just a perceived difference in severity. There is a ton of research coming out about how people with Long Covid are much more likely to have HSD/hEDS at a rate that makes no sense unless the general population prevalence is at 2%.

moltar 3y ago

Interesting. Do you have more information? Thank you.

cjbgkagh 3y ago
Sure; the book Stahl's Essential Psychopharmacology is quite approachable and goes in depth on treatment and effects of various disorders including ADHD. It’s not perfect but nothing is. The https://ldnresearchtrust.org https://ldnresearchtrust.org is probably the best source for LDN information. Sarah Wilson of ‘I quit sugar’ fame talks about her experiences in quitting sugar. She repeatedly acknowledges that while quitting sugar is beneficial for most people it is of particular benefit to a small percentage of the population that are most likely to have ADHD. Her N of 1 experimentation is really good and highly aplicable to those similarity impacted by sugar in a way that more general research is not. The 2% of undiagnosed hEDS is probably most easily found by looking at comorbidities (https://ohtwist.com/about-eds/comorbidities https://ohtwist.com/about-eds/comorbidities) which occur within families on an autosomal dominant basis. Due to the perceived rarity of hEDS people with the more common milder form are often classified as Hypermobility Spectrum Disorder (HSD) but follow up research has found no real difference between hEDS and HSD, just a perceived difference in severity. There is a ton of research coming out about how people with Long Covid are much more likely to have HSD/hEDS at a rate that makes no sense unless the general population prevalence is at 2%.