4 ms·
It is highly likely that very old men like the one the article discusses, are likely to have accumulated potentially damaging somatic variants in DNA that will
by janeway 3y ago
It is highly likely that very old men like the one the article discusses, are likely to have accumulated potentially damaging somatic variants in DNA that will be passed onto their child.
- User23 3y agoNo, it’s really not. The rate of increased birth defects for older fathers is quite small[1]. It’s advanced maternal age where you see the multiple orders of magnitude greater chance of serious problems. [1] https://pubmed.ncbi.nlm.nih.gov/17164268/ https://pubmed.ncbi.nlm.nih.gov/17164268/
- janeway 3y agoIt’s fair that my comment is not supported. The evidence is sporadic in both directions in fact. The paper linked is a big study but very weak association results. Here is a good review that includes the most plausible interpretation of the genetics. https://pubmed.ncbi.nlm.nih.gov/36833413/ https://pubmed.ncbi.nlm.nih.gov/36833413/