I can't speak for the most recent version, but I regularly pass 200+ waypoints to a fork of OSRM 4.9 and it works fine. If you were to use the Node/Python bindi

I can't speak for the most recent version, but I regularly pass 200+ waypoints to a fork of OSRM 4.9 and it works fine. If you were to use the Node/Python bindings and hence avoid any webserver limitations you should be ok.